Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing

Acta Biomaterialia
Mathilde ChampeauM G de Oliveira

Abstract

Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, delivering NO to wounds at appropriate rates and doses requires new biomaterial-based strategies. Here, we describe the development of supramolecular interpolymer complex hydrogels comprising PEO-PPO-PEO (F127) micelles embedded in a poly(acrylic acid) (PAA) matrix, with S-nitrosoglutathione (GSNO) molecules dissolved in the hydrophilic domain. We show that PAA:F127/GSNO hydrogels start releasing NO upon hydration at rates controlled by their rates of water absorption. SAXS measurements indicate that the supramolecular structure of the hydrogels retains long-range order domains of F127 micelles. The PAA/F1227 hydrogels displayed dense morphologies and reduced rates of hydration. The NO release rates remain constant over the first 200 min, are directly correlated with the hydration rates of the PAA:F127/GSNO hydrogels, and can be modulated in the range of 40 nmol/g h to 1.5 μmol/g h by changing the PAA:F127 mass ratio. Long-term NO-release profiles over 5 days are governed by the first-order exponential decay of GSNO, with half-lives in the range of 0.5-3.4 days. A preliminary in vivo study on full-thickness excisional wounds in mice showed t...Continue Reading

Citations

Mar 2, 2019·Annual Review of Biomedical Engineering·Lucília P da SilvaAlexandra P Marques
Jun 25, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Suan P QuahSurita R Bhatia
Apr 25, 2020·Journal of Tissue Engineering and Regenerative Medicine·Valéria C O PóvoaMarcelo G de Oliveira
Aug 29, 2020·Biomaterials Science·Susan OliverCyrille Boyer
May 21, 2021·Biomaterials Science·Zejun XuJun Wu
Jun 5, 2021·Soft Matter·Murilo I SantosMarcelo G de Oliveira
Jun 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min WuJinshan Guo
Aug 11, 2021·ACS Nano·Yongping LiangBaolin Guo
Nov 19, 2020·ACS Applied Materials & Interfaces·Sama GhaleiHitesh Handa
Jan 24, 2020·Ultrasonics Sonochemistry·Yihui WangXiaobing Wang

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