Supramolecular self-assembled drug delivery system (SADDs) of vancomycin and tocopherol succinate as an antibacterial agent: in vitro, in silico and in vivo evaluations.

Pharmaceutical Development and Technology
Mohammed SalihThirumala Govender

Abstract

In this study self-assembled drug delivery system (SADDs) composed of a hydrophobic d-α-tocopherol succinate (TS) and a hydrophilic vancomycin (VCM) were formulated, and its potential for enhancing the antibacterial activity of VCM against Staphylococcus aureus (SA) and Methicillin-resistant Staphylococcus aureus (MRSA) were explored. The SADDs were synthesized via supramolecular complexation, then characterized for in silico, in vitro and in vivo studies. In silico studies confirmed the self-assembly of VCM/TS into NPs. The size, surface charge and drug loading of the SADDs was ˂100 nm, -27 mV and 68%, respectively. The SADDs were non-hemolytic and biosafe. A sustained release of VCM from SADDs was noted, with 52.2% release after 48 hr. The in vitro antibacterial test showed a twofold decrease in Minimum inhibitory concentration (MIC) against SA and MRSA, and a significantly higher reduction in MRSA biofilms compared to bare VCM. Further, in silico studies confirmed strong and stable binding of TS to MRSA efflux pumps. The in vivo study using mice skin infection models showed a 9.5-fold reduction in bacterial load after treatment with SADDs, in comparison with bare VCM. These findings affirmed that VCM/TS NPs as a promising no...Continue Reading

References

Jun 18, 1993·Science·J M Lehn
Jul 2, 1998·Journal of Pharmaceutical Sciences·S H YalkowskyG H Ward
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·UNKNOWN European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and In
Jun 28, 2001·International Journal of Pharmaceutics·P B NielsenH G Kristensen
Oct 6, 2001·Current Opinion in Microbiology·P N Markham, A A Neyfakh
Nov 25, 2003·Nature·Eran RabaniLouis E Brus
Nov 25, 2003·Nature·Thien-Fah MahGeorge A O'Toole
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Elisabeth KugelbergDiarmaid Hughes
Oct 4, 2005·Journal of Computational Chemistry·David A CaseRobert J Woods
Nov 8, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Deshan YuTamara Minko
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Dec 27, 2005·International Journal of Pharmaceutics·Vasiliki PapadopoulouPanos Macheras
Dec 28, 2007·International Journal of Pharmaceutics·Young-Il JeongJae-Woon Nah
Jan 29, 2008·Recent Patents on Anti-infective Drug Discovery·Françoise Van BambekeVing J Lee
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Puja SapraIvan D Horak
Jun 17, 2008·Critical Care : the Official Journal of the Critical Care Forum·Thomas G Slama
Jul 9, 2008·Nano Letters·Marina A DobrovolskaiaScott E McNeil
Feb 3, 2009·Experimental and Molecular Pathology·Rajesh Singh, James W Lillard
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Mar 6, 2010·Advances in Experimental Medicine and Biology·B Keith English, Aditya H Gaur
Jul 22, 2010·Angewandte Chemie·Katrin KnopUlrich S Schubert
Mar 23, 2011·Current Opinion in Hematology·Warren L Lee, W Conrad Liles
Sep 17, 2011·Virulence·Nathan K ArcherMark E Shirtliff
Aug 16, 2012·Accounts of Chemical Research·Motao ZhuYuliang Zhao
Sep 4, 2012·Journal of Microbiological Methods·Mariana FittipaldiFrancesc Codony
Dec 25, 2012·International Journal of Pharmaceutics·Sonali BoseBozena Michniak-Kohn
Dec 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongfang ZhangMeihua Sui
Apr 10, 2013·The Open Microbiology Journal·Sofia Santos CostaIsabel Couto
Jun 7, 2013·Advanced Materials·Jinqiang WangZhongwei Gu
Apr 29, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M D MaciàA Oliver
Jul 22, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Weiwei GaoLiangfang Zhang
Aug 1, 2014·Journal of the American Chemical Society·Ping HuangDeyue Yan
Nov 27, 2014·Advanced Healthcare Materials·Ulyana ShimanovichAharon Gedanken

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Citations

Jul 27, 2021·Advanced Materials Technologies·Jill ZiesmerGeorgios A Sotiriou
Aug 2, 2021·International Journal of Pharmaceutics·Usri H IbrahimThirumala Govender
Aug 21, 2021·Colloids and Surfaces. B, Biointerfaces·Calvin A OmoloThirumala Govender

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