Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5

Journal of Structural Biology
Klaus BrandenburgMichel H J Koch

Abstract

Lipopolysaccharides (LPS) belong to the strongest immune-modulating compounds known in nature, and are often described as pathogen-associated molecular patterns (PAMPs). In particular, at higher concentrations they are responsible for sepsis and the septic shock syndrome associated with high lethality. Since most data are indicative that LPS aggregates are the bioactive units, their supramolecular structures are considered to be of outmost relevance for deciphering the molecular mechanisms of its bioactivity. So far, however, most of the data available addressing this issue, were published only for the lipid part (lipid A) and the core-oligosaccharide containing rough LPS, representing the bioactive unit. By contrast, it is well known that most of the LPS specimen identified in natural habitats contain the smooth-form (S-form) LPS, which carry additionally a high-molecular polysaccharide (O-chain). To fill this lacuna and going into a more natural system, here various wild-type (smooth form) LPS including also some LPS fractions were investigated by small-angle X-ray scattering with synchrotron radiation to analyze their aggregate structure. Furthermore, the influence of a recently designed synthetic anti-LPS peptide (SALP) Pep...Continue Reading

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Citations

Aug 11, 2018·Frontiers in Immunology·Lena HeinbockelKlaus Brandenburg
Dec 21, 2017·International Journal of Molecular Sciences·Wilmar CorreaFriedrich von Wintzingerode
Feb 6, 2021·International Journal of Molecular Sciences·Lena HeinbockelKlaus Brandenburg
Nov 20, 2020·Expert Review of Anti-infective Therapy·Klaus BrandenburgPatrick Garidel

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