Supramolecular subphthalocyanine complexes-cellular uptake and phototoxicity.

Chemical Communications : Chem Comm
Justin DubbertJens Voskuhl

Abstract

In this communication we report on the synthesis and application of axially functionalized boron-subphthalocyanines (SubPC) which are able to form host-guest complexes with cyclodextrins. Here, a tert-butylphenyl substituted SubPC was investigated concerning its complexation with β-cyclodextrin (β-CD) and a β-cyclodextrin polymer. NMR-titrations showed the formation of a 1 : 1 complex with β-CD. These assemblies were analyzed for their cellular distribution as well as their phototoxicity towards HeLa cells.

References

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Methods Mentioned

BETA
fluorescence
NMR
fluorescence microscopy
fluorescence tomography
Assay

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