Supramolecularly directed rotary motion in a photoresponsive receptor

Nature Communications
Sander J Wezenberg, Ben L Feringa

Abstract

Stimuli-controlled motion at the molecular level has fascinated chemists already for several decades. Taking inspiration from the myriad of dynamic and machine-like functions in nature, a number of strategies have been developed to control motion in purely synthetic systems. Unidirectional rotary motion, such as is observed in ATP synthase and other motor proteins, remains highly challenging to achieve. Current artificial molecular motor systems rely on intrinsic asymmetry or a specific sequence of chemical transformations. Here, we present an alternative design in which the rotation is directed by a chiral guest molecule, which is able to bind non-covalently to a light-responsive receptor. It is demonstrated that the rotary direction is governed by the guest chirality and hence, can be selected and changed at will. This feature offers unique control of directional rotation and will prove highly important in the further development of molecular machinery.

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Citations

Feb 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyong JiaLiangliang Zhu
May 11, 2019·Organic & Biomolecular Chemistry·Sk Atiur RahamanSubhajit Bandyopadhyay
Jun 26, 2020·Angewandte Chemie·Mohamed FaresPhilip A Gale
Jul 30, 2019·Chemistry, an Asian Journal·Jing-Jing YuDa-Hui Qu
Jan 17, 2020·ChemPlusChem·Madoori Mrinalini, Seelam Prasanthkumar
Mar 30, 2020·Angewandte Chemie·David Villarón, Sander J Wezenberg
Feb 19, 2021·Physical Chemistry Chemical Physics : PCCP·Elena Kolodzeiski, Saeed Amirjalayer
May 5, 2021·Chemistry : a European Journal·Ludwig A HuberHenry Dube
Nov 12, 2020·The Journal of Physical Chemistry. B·Elena Kolodzeiski, Saeed Amirjalayer
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Apr 18, 2019·The Journal of Organic Chemistry·Jiyoung JungDongwhan Lee
Nov 13, 2018·Journal of the American Chemical Society·Zoran Kokan, Michał J Chmielewski
Sep 25, 2018·Journal of the American Chemical Society·Dan LehnherrMikhail Reibarkh
Aug 16, 2019·Chemical Reviews·Massimo BaronciniAlberto Credi
Nov 13, 2020·Journal of the American Chemical Society·Thomas S C MacDonaldJonathon E Beves
Nov 18, 2020·The Journal of Physical Chemistry. a·Shasha LvJun Jiang
Oct 1, 2021·Chemical Society Reviews·Jana VolarićBen L Feringa
Oct 8, 2021·Organic & Biomolecular Chemistry·Aidan KerckhoffsMatthew J Langton
Oct 5, 2021·Chemistry : a European Journal·David VillarónSander J Wezenberg
Nov 30, 2021·Chemical Communications : Chem Comm·Shenglun Xiong, Qing He
Dec 22, 2021·Journal of the American Chemical Society·Sander J WezenbergPhilip A Gale

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Methods Mentioned

BETA
circular dichroism
NMR

Software Mentioned

BindFit

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