Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Barbara R CardosoAshley I Bush

Abstract

Insufficient supply of selenium to antioxidant enzymes in the brain may contribute to Alzheimer's disease (AD) pathophysiology; therefore, oral supplementation may potentially slow neurodegeneration. We examined selenium and selenoproteins in serum and cerebrospinal fluid (CSF) from a dual-dose 24-week randomized controlled trial of sodium selenate in AD patients, to assess tolerability, and efficacy of selenate in modulating selenium concentration in the central nervous system (CNS). A pilot study of 40 AD cases was randomized to placebo, nutritional (0.32 mg sodium selenate, 3 times daily), or supranutritional (10 mg, 3 times daily) groups. We measured total selenium, selenoproteins, and inorganic selenium levels, in serum and CSF, and compared against cognitive outcomes. Supranutritional selenium supplementation was well tolerated and yielded a significant (p < 0.001) but variable (95% CI = 13.4-24.8 μg/L) increase in CSF selenium, distributed across selenoproteins and inorganic species. Reclassifying subjects as either responsive or non-responsive based on elevation in CSF selenium concentrations revealed that responsive group did not deteriorate in Mini-Mental Status Examination (MMSE) as non-responsive group (p = 0.03). P...Continue Reading

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Citations

Jan 12, 2019·British Journal of Pharmacology·Sara NiksereshtScott Ayton
Feb 13, 2020·Journal of Neurotrauma·Jessica M CollinsJenna M Ziebell
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Oct 29, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew Gleason, Ashley I Bush
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Jan 15, 2021·The Science of the Total Environment·Mohammad NaderiRaymond W M Kwong
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Aug 8, 2021·International Journal of Molecular Sciences·Tien-Wei YuChieh-Hsin Lin
Sep 24, 2021·Journal of Neurochemistry·Md JakariaScott Ayton

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Methods Mentioned

BETA
size exclusion chromatography

Clinical Trials Mentioned

NCT00040378

Software Mentioned

GraphPad
Prism
Adobe Illustrator CC
Statistical Package for the Social Sciences

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