Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer

Human Reproduction
Nigel PereiraZev Rosenwaks

Abstract

Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles? Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles. The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW. Retrospective cohort study of normal responder patients, <40 years old, undergoing fresh IVF-ET cycles resulting in live singleton births between January 2005 and June 2014. A total of 6419 patients had live births after fresh IVF-ET during the study period, of which 2348 (36.6%) patients were excluded due to multiple gestation, vanishing twins or incomplete records. Perinatal outcomes recorded for all patients included birth weight, gestational age (GA) at delivery, mode of delivery and gender. Term birth, preterm birth (PTB) and LBW incidence proportions were plotted against E2 level on the day of trigger. The term LBW incidence proportion (i....Continue Reading

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Citations

Mar 14, 2018·Nature Reviews. Urology·Zev Rosenwaks, Nigel Pereira
Jan 8, 2019·Human Fertility : Journal of the British Fertility Society·Julija GorodeckajaMichael Summers
Apr 18, 2019·Clinical Obstetrics and Gynecology·Nigel PereiraZev Rosenwaks
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Feb 23, 2020·Human Reproduction Open·Catherine M CastilloDaniel R Brison
Feb 23, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alexandra NoëlArthur Penn
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Apr 15, 2021·Reproductive Medicine and Biology·Yukiko Katagiri, Yuko Tamaki
May 12, 2021·Journal of Developmental Origins of Health and Disease·Junwei ZhangLijun Sun

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