Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?

PloS One
Giannantonio SpenaMarco Maria Fontanella

Abstract

To date, few parameters have been found that can aid in patient selection and surgical strategy for eloquent area gliomas. The aim of the study was to analyze preoperative and intraoperative factors that can predict functional outcome and extent of resection in eloquent area tumors. A retrospective analysis was conducted on 60 patients harboring supratentorial gliomas in eloquent areas undergoing awake surgery. The analysis considered clinical, neuroradiologic (morphologic), intraoperative, and postoperative factors. End-points were extent of resection (EOR) as well as functional short- and long-term outcome. Postoperatively, MRI objectively established the EOR. χ(2) analyses were used to evaluate parameters that could be predictive. Multivariate logistic regression analyses were used to evaluate the best combination to predict binary positive outcomes. In 90% of the cases, subcortical stimulation was positive in the margins of the surgical cavity. Postoperatively, 51% of the patients deteriorated but 90% of the patients regained their preoperative neurological score. Factors negatively affecting EOR were volume, degree of subcortical infiltration, and presence of paresis (P<0.01). Sharp margins and cystic components were more ...Continue Reading

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Citations

May 26, 2015·World Neurosurgery·Randy L Jensen
May 9, 2014·Neurocase·Giannantonio SpenaMarco Maria Fontanella
Jan 24, 2019·JCO Clinical Cancer Informatics·Domenique M J MüllerPhilip C De Witt Hamer
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Nov 10, 2020·Cancer Letters·Tao JiangUNKNOWN Asian Glioma Genome Atlas (AGGA) network

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Methods Mentioned

BETA
surgical resection
biopsy
total resection

Software Mentioned

SPSS

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