Suramin alleviates glomerular injury and inflammation in the remnant kidney.

PloS One
Na LiuShougang Zhuang

Abstract

Recently, we demonstrated that suramin, a compound that inhibits the interaction of multiple cytokines/growth factors with their receptors, inhibits activation and proliferation of renal interstitial fibroblasts, and attenuates the development of renal interstitial fibrosis in the murine model of unilateral ureteral obstruction (UUO). However, it remains unclear whether suramin can alleviate glomerular and vascular lesions, which are not typical pathological changes in the UUO model. So we tested the efficacy of suramin in the remnant kidney after 5/6 nephrectomy, a model characterized by the slow development of glomerulosclerosis, vascular sclerosis, tubulointerstitial fibrosis and renal inflammation, mimicking human disease. 5/6 of normal renal mass was surgically ablated in male rats. On the second week after surgery, rats were randomly divided into suramin treatment and non-treatment groups. Suramin was given at 10 mg/kg once per week for two weeks. In the remnant kidney of mice receiving suramin, glomerulosclerosis and vascular sclerosis as well as inflammation were ameliorated. Suramin also attenuated tubular expression of two chemokines, monocyte chemoattractant protein-1 and regulated upon expression normal T cell expre...Continue Reading

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Citations

Nov 30, 2013·Advances in Urology·Luciana Mazzei, Walter Manucha
Jun 23, 2016·International Journal of Molecular Sciences·Feng Liu, Shougang Zhuang
Sep 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun-Jin AnKwan-Kyu Park
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Na LiuShougang Zhuang
Jun 28, 2012·The Journal of Pharmacology and Experimental Therapeutics·Midhun C KorrapatiRick G Schnellmann
Dec 15, 2015·American Journal of Physiology. Renal Physiology·Tess Victoria DupreLeah J Siskind
Jul 18, 2020·The Journal of Cell Biology·Manuel ChiusaAmbra Pozzi
Jan 16, 2015·American Journal of Physiology. Cell Physiology·Yanli YanShougang Zhuang
Jan 30, 2019·International Journal of Molecular Sciences·Eun Hui BaeSoo Wan Kim
Aug 18, 2020·Expert Opinion on Emerging Drugs·Sujit DebnathAbdelwahab Omri
Oct 30, 2018·Frontiers in Medicine·Ana Carolina de BragançaRildo Aparecido Volpini

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