PMID: 7516802Jan 1, 1994Paper

Suramin and reactive blue 2 are antagonists for a newly identified purinoceptor on rat megakaryocyte

British Journal of Pharmacology
H UneyamaN Akaike

Abstract

1. The effects of purinoceptor antagonists on ATP-induced oscillatory K(+)-currents in rat isolated megakaryocytes were investigated. 2. Both reactive blue-2 (RB-2), a selective antagonist of the P2Y purinoceptor, purinoceptor, at concentrations of 0.3-10 microM and suramin, a non-selective P2 purinoceptor antagonist, at 1-30 microM blocked the ATP-induced oscillation in a concentration-dependent manner. 3. RB-2 and suramin also blocked the ADP-induced K(+)-current oscillation at the same concentration range as in the case of ATP. However, both suramin and RB-2 had no effect on thrombin- and inositol 1,4,5-trisphosphate (IP3)-induced K+ current oscillation, indicating that they act as specific purinoceptor antagonists. 4. Thus, the purinoceptors on megakaryocytes show the properties of the P2 subtype according to their blockade by antagonists.

References

Jul 1, 1992·Neuroreport·H UneyamaN Akaike
Mar 1, 1991·Journal of Neurophysiology·T NakagawaN Akaike
Aug 1, 1988·The Journal of General Physiology·R Horn, A Marty
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Feb 1, 1988·British Journal of Pharmacology·P M Dunn, A G Blakeley

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Citations

Jan 29, 1997·European Journal of Pharmacology·C UneyamaN Akaike
Apr 22, 2006·Thrombosis Research·Masahiro Ikeda
Aug 12, 2015·Purinergic Signalling·Geoffrey Burnstock
Nov 12, 2016·International Journal of Food Science·Leonardo Gomes Braga FerreiraRômulo José Soares-Bezerra
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Oct 27, 1998·Current Eye Research·S P SrinivasJ A Bonanno
Jul 27, 2000·American Journal of Physiology. Cell Physiology·E NakamuraF Izumi

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