PMID: 11342151May 9, 2001Paper

Surface activity and film formation from the surface associated material of artificial surfactant preparations

Biochimica Et Biophysica Acta
M PalmbladS Schürch

Abstract

Surfactant proteins B and C (SP-B and SP-C) are present in natural derived surfactant preparations used for treatment of respiratory distress syndrome. Herein the surface activity of an SP-C analogue (SP-C(LKS)), a hybrid peptide between SP-C and bacteriorhodopsin (SP-C/BR) and a model peptide (KL(4)) was studied with a captive bubble surfactometer (CBS). The peptides were mixed with either 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)/phosphatidylglycerol (PG) (7:3, by weight) or DPPC/PG/palmitic acid (68:22:9, by weight) at a concentration of 1 mg/ml in HEPES buffer, pH 6.9 and a polypeptide/lipid weight ratio of 0.02--0.03. In some lipid/peptide preparations also 2% of SP-B was included. Adsorption, monitored as surface tension vs. time for 10 min after bubble formation did not show discernible differences for the whole set of preparations. Equilibrium surface tensions of approximately 25 mN/m were reached after 5--10 min for all preparations, although those with SP-C/BR appeared not to reach end point of adsorption within 10 min. Area compression needed to reach minimum surface tension of 0.5--2.0 mN/m was least for the KL(4) preparation, about 13% in the first cycle. 3% SP-C(LKS) in DPPC:PG (7:3, by weight) reached mi...Continue Reading

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Citations

Apr 19, 2007·Acta Pharmacologica Sinica·Ying JiYuan-Ying Pei
Jul 22, 2008·Journal of Lipid Research·Andrea RavasioThomas Haller
Nov 3, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Yi Y ZuoA Wilhelm Neumann
Dec 13, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Gang Ma, Heather C Allen

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