Surface adhesion molecule expression on human blood cells induced by vascular graft materials in vitro

Journal of Biomedical Materials Research
P SwartbolL Norgren

Abstract

The expression of surface adhesion molecules on granulocytes, monocytes (CD11a, CD11b, CD11c, CD18, L-selectin), and platelets (P-selectin, gpIIb-IIIa) was determined after incubation with different graft surfaces [expanded polytetrafluoroethylene (ePTFE) or woven Dacron]. Woven Dacron grafts upregulated the CD11b and CD11c surface antigens on both granulocytes and monocytes. Both graft materials demonstrated increased expression of CD11a and CD18 adhesion molecules on white blood cells at 30 min, followed by a downregulation. Maximum L-selectin expression was seen at 120 min on granulocytes and at 90 min on monocytes without differences between the graft materials. A rapid downregulation of gpIIb-IIIa complexes on platelets was noticed, while no expression of platelet P-selectin molecules was observed. In conclusion, both graft materials induced alteration of the white blood cell adhesion molecule expression, but the intensity and time course were dependent on the cell type and the graft material, suggesting that different mechanisms might be implicated. The expression of platelet surface antigens was less clearly influenced. The clinical significance of an enhanced cell surface antigen receptor expression caused by woven Dacr...Continue Reading

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Citations

Feb 9, 2002·Journal of Biomedical Materials Research·Rene S Rosenson-SchlossPrabhas V Moghe
Jan 29, 2011·Seminars in Immunopathology·James M Anderson, Amy K McNally
Dec 3, 2008·Langenbeck's Archives of Surgery·Joerg TautenhahnBrigitte Koenig
Aug 9, 2001·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·T HagenaarsM R van Sambeek
Jan 27, 2016·Polski przeglad chirurgiczny·Frank MeyerJoerg Tautenhahn
May 27, 2004·Journal of Biomedical Materials Research. Part a·Yue ZhouRoger E Marchant
Feb 13, 2007·Biomacromolecules·Nattharika AumsuwanMarek W Urban

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