Surface anaesthetic properties of the new local anaesthetic amid etidocaine (Duranest): A laboratory evaluation.

British Journal of Anaesthesia
S B Akerman

Abstract

The surface local anaesthetic properties of the new local anaesthetic amid etidocaine (Duranest) were studied in experimental animals. Etidocaine produced topical local anaesthesia of high intensity, rapid onset and with a comparatively long duration of action following corneal, intranasal and intratracheal application. The surface anaesthetic activity of etidocaine was substantially greater than that of lignocaine, similar to that of bupivacaine but less than that of amethocaine. When applied to the mucous surfaces of the nose and the respiratory tract, etidocaine was less toxic than amethocaine and bupivacaine but more toxic than lignocaine. The data justify a clinical evaluation of etidocaine as a surface anaesthetic.

Citations

Jan 1, 1984·British Journal of Clinical Pharmacology·A McBurneyJ W Ward
Jan 24, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Bradley CarofinoAugustus D Mazzocca
Aug 1, 1981·Journal of Dental Research·L P Gangarosa
May 1, 1979·Contact Dermatitis·S FregertI Thelin

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