PMID: 6984001Jan 1, 1982Paper

Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development

Immunological Reviews
R L Coffman

Abstract

The first part of this article discusses the isolation and characterization of several monoclonal antibodies to the B lineage-specific surface molecule, B220. B220 was shown to be expressed on precursors of B cells by the demonstration that removal of B220+ cells from B cell-depleted bone marrow removes the ability of bone marrow to regenerate B cells. Although these antibodies recognize a broad range of differentiation stages within the B lineage, they can be used to isolate highly enriched populations of pre-B cells from mouse bone marrow. We also describe the use of antibodies to the surface markers B220 and ThB to define two sequential stages of pre-B cell differentiation. A simplified diagram of our current view of the B lineage differentiation sequence is shown in Figure 4. No attempt has been made to include the various functionally defined B cell subsets on this diagram since we know almost nothing about the expression of these two surface markers on them. This model reflects an assumption that the early part of B cell differentiation is a linear rather than a branching pathway. At present, there is no evidence for a branching pathway, but little evidence against it either. B220 is the first B cell-specific molecule kno...Continue Reading

References

Mar 15, 1979·Nature·D P Lane, L V Crawford
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A B DeLeoL J Old
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Apr 1, 1973·The Journal of Experimental Medicine·L LafleurR A Phillips
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E SidenD Baltimore
Sep 10, 1981·Nature·F Lepault, I L Weissman
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L V CrawfordJ Taylor-Papadimitriou
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C Nottenburg, I L Weissman
Feb 1, 1981·The Journal of Experimental Medicine·R L Coffman, I L Weissman
Apr 1, 1981·European Journal of Immunology·D S Dessner, M R Loken
Feb 19, 1981·Nature·R L Coffman, I L Weissman

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Citations

Nov 1, 1990·International Journal of Cell Cloning·M MuirheadR G Smith
Jan 1, 1992·International Journal of Cell Cloning·K Dorshkind, K S Landreth
May 1, 1992·International Journal of Cell Cloning·F LepaultJ F Bach
Apr 25, 2000·Biochemical and Biophysical Research Communications·M D GriffinR Kumar
Jan 1, 1992·International Journal of Clinical & Laboratory Research·E S RavechéB Peng
Jan 1, 1987·Immunologic Research·W D Cook
Mar 16, 1984·Journal of Immunological Methods·C A WhitlockO N Witte
Jul 6, 1989·Journal of Immunological Methods·T M Jung, M O Dailey
Jul 20, 1990·Journal of Immunological Methods·P H NibberingR Van Furth
Jun 28, 1995·Journal of Immunological Methods·J RoesK Rajewsky
Jun 14, 1996·Journal of Immunological Methods·T L ten HagenI A Bakker-Woudenberg
Oct 16, 1996·Journal of Immunological Methods·E Lagasse, I L Weissman
Jan 1, 1984·Developmental and Comparative Immunology·K S Landreth, P W Kincade
Jan 1, 1984·Developmental and Comparative Immunology·E S MedlockP W Kincade
Feb 1, 1995·Molecular Immunology·M C GagneraultF Lepault
Apr 1, 1993·Current Opinion in Immunology·J Chen, F W Alt
Apr 1, 1995·Current Opinion in Immunology·F MelchersJ Andersson
May 1, 1997·European Journal of Pharmacology·B HomeyP Lehmann
Dec 9, 1998·Clinical and Experimental Immunology·L A DielemanE P Van Rees
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A ReynaudJ C Weill
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K L HolmesH C Morse
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M HagiyaH Sakano
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R R HardyL A Herzenberg
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M L ThomasI S Trowbridge
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D RennickL Gemmell
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaR R Hardy
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T KinashiT Honjo
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E AdamsC C Goodnow
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Z Ben-SassonW E Paul
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A ScherleO N Witte
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G YamadaT Taniguchi
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K SpriggsC R Maliszewski
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T E CostaM C Nussenzweig
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T TanakaW E Paul

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