PMID: 6979246May 1, 1982Paper

Surface antigenic phenotypes of human T-cell leukemia corresponding to those of post-thymic T cells

American Journal of Hematology
Y IshiiK Kikuchi

Abstract

Leukemic cells from eight adult patients with various types of T-cell leukemias, including one patient with lymphosarcoma cell leukemia (T-LSL), two patients with chronic lymphocytic leukemia (T-CLL), and five patients with adult T-cell leukemia (ATL), were analyzed for their surface antigenic phenotypes with a series of monoclonal antibodies directing to human T-cell differentiation antigens. All of the leukemic T cells studied were regarded as being of post-thymic T-cell origin because of their ability to form rosettes with sheep red cells under the condition at 4 degrees C but not 37 degrees C as well as the expression of human Ly-1-like but not TL-like antigen on their cell surfaces. By using monoclonal antibodies to a variety of human of three distinct categories. Thus, one patient with T-LSL had cells with Leu-1+2a+3a+ phenotype, which might reflect possible post-thymic precursor T cells, whereas one patient with T-CLL had cells with the same phenotype (Leu-1+2a+3a-) as normal cytotoxic/suppressor T cells. The latter cells also expressed Ia antigens as defined by monoclonal antihuman Ia antibody. The remaining six cases, including one T-CLL and five ATL patients had leukemic cells with the same phenotype (Leu-1+2a-3a+) as...Continue Reading

References

Jan 1, 1978·Immunological Reviews·O Stutman
Mar 1, 1976·The Journal of Experimental Medicine·Z NagyB Pernis
Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Apr 10, 1975·The New England Journal of Medicine·R McCaffreyD Baltimore
Jan 1, 1981·American Journal of Hematology·J FujimotoK Kikuchi
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman

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Citations

Dec 1, 1983·American Journal of Hematology·J P FarcetH Rochant

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