Surface-Based Analyses of Anatomical Properties of the Visual Cortex in Macular Degeneration

PloS One
Doety PrinsFrans W Cornelissen

Abstract

Macular degeneration (MD) can cause a central visual field defect. In a previous study, we found volumetric reductions along the entire visual pathways of MD patients, possibly indicating degeneration of inactive neuronal tissue. This may have important implications. In particular, new therapeutic strategies to restore retinal function rely on intact visual pathways and cortex to reestablish visual function. Here we reanalyze the data of our previous study using surface-based morphometry (SBM) rather than voxel-based morphometry (VBM). This can help determine the robustness of the findings and will lead to a better understanding of the nature of neuroanatomical changes associated with MD. The metrics of interest were acquired by performing SBM analysis on T1-weighted MRI data acquired from 113 subjects: patients with juvenile MD (JMD; n = 34), patients with age-related MD (AMD; n = 24) and healthy age-matched controls (HC; n = 55). Relative to age-matched controls, JMD patients showed a thinner cortex, a smaller cortical surface area and a lower grey matter volume in V1 and V2, while AMD patients showed thinning of the cortex in V2. Neither patient group showed a significant difference in mean curvature of the visual cortex. Th...Continue Reading

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Citations

Jan 25, 2017·NeuroImage. Clinical·Sónia FerreiraMiguel Castelo-Branco
Aug 3, 2017·Experimental Brain Research·Caitlin O'ConnellRakié Cham
Jun 16, 2018·Visual Neuroscience·Stephen RamanoëlCarole Peyrin
Dec 5, 2019·Investigative Ophthalmology & Visual Science·Rachel L W HansonAntony B Morland
Sep 26, 2020·Frontiers in Neuroscience·Raffaele NuzziAlessio Vitale
Jun 25, 2018·Brain Structure & Function·Nicolae SandaMichel Thiebaut de Schotten
Aug 8, 2018·Frontiers in Behavioral Neuroscience·Michael Leon, Cynthia Woo
Dec 24, 2019·Translational Vision Science & Technology·Elisa CastaldiMaria Concetta Morrone
May 4, 2018·Brain and Language·Visar BerishaCorianne Rogalsky

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