Surface biofunctional drug-loaded electrospun fibrous scaffolds for comprehensive repairing hypertrophic scars

Biomaterials
Liying ChengWenguo Cui

Abstract

Incorporation of bioactive drugs and biofunctionalization of polyester fibrous scaffolds are essential means to improve their bio-functions and histocompatibility for regenerative medicine. However, it is still a challenge to biofunctionalize such drug carriers via traditional biochemical methods while maintaining their properties without changes in drug activity and loading ratio. Here, we demonstrated a facile approach for biofunctionalization of PLGA fibrous scaffolds with various molecules (i.e., PEG polymer, RGD peptide and bFGF growth factor for cell repellent, adhesion and proliferation, respectively) via mussel-Inspired poly(dopamine) (PDA) coating in aqueous solution. By virtue of the mild and efficient nature of this approach, the drug-loaded PLGA fibers could be easily biofunctionalized and showed negligible effects on the scaffold properties, especially drug activity and loading ratio. Further, in vivo study showed that, a ginsenoside-Rg3-loaded fibrous scaffold functionalized with bFGF growth factor could not only promote the early-stage wound healing in rabbit ear wounds (bio-signal from bFGF), but also inhibit later-stage hypertrophic scars formation (release of Rg3 drug). Therefore, the mussel-inspired method fo...Continue Reading

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Citations

Oct 26, 2016·Journal of the American Chemical Society·Guoqing PanHuilin Yang
Jan 25, 2017·ACS Applied Materials & Interfaces·Hatef Ghasemi HamidabadiMazaher Gholipourmalekabadi
Apr 12, 2019·Advanced Healthcare Materials·Tingting XuBo Chi
Jul 5, 2019·Advanced Materials·Xiaoxuan ZhangYuanjin Zhao
Jul 2, 2019·The International Journal of Lower Extremity Wounds·Fahimeh RezaieHojjat Naderi-Meshkin
Aug 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pingyun YuanYan Jin
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Apr 10, 2020·Research : a Science Partner Journal·Liang ChengWenguo Cui
Jul 23, 2020·APL Bioengineering·Ziqian LiuXiaoling Liu
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Feb 13, 2021·International Journal of Molecular Sciences·Luis Castillo-HenríquezJosé Vega-Baudrit
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Nov 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Kuan ZhangHongyu Zhang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Mahdieh AlimohammadiSeyed Ali Mousavi Shaegh
Jan 15, 2021·ACS Applied Materials & Interfaces·Wanqing WengYuanjin Zhao

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