Surface biology of DNA by atomic force microscopy

Annual Review of Physical Chemistry
H G Hansma

Abstract

The atomic force microscope operates on surfaces. Since surfaces occupy much of the space in living organisms, surface biology is a valid and valuable form of biology that has been difficult to investigate in the past owing to a lack of good technology. Atomic force microscopy (AFM) of DNA has been used to investigate DNA condensation for gene therapy, DNA mapping and sizing, and a few applications to cancer research and to nanotechnology. Some of the most exciting new applications for atomic force microscopy of DNA involve pulling on single DNA molecules to obtain measurements of single-molecule mechanics and thermodynamics.

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Methods Mentioned

BETA
AFM
electron microscopy
electron
transfection
PCR
Atomic Force Microscopy
electrophoresis
force measurement

Software Mentioned

NIH Image
Scion Image

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