Surface characterization of porous, biocompatible protein polymer thin films

Biomaterials
C J BuchkoDavid C Martin

Abstract

Genetically engineered protein polymer coatings are intended to improve the performance of implantable neural prosthetic devices. To facilitate device integration with tissue, three-dimensionally structured protein polymer films were deposited on the devices using electrostatic atomization and gas-evolution foaming. Periodic features and the length-scale dependence of the surface roughness were identified in topographic data collected using scanning probe microscopy. Using the power spectral density of surface data, the influence of process parameters on the surface roughness of protein polymer thin films was examined. Details of surface topography are known to influence biological behavior, and the method presented was capable of quantifying the evolution of surface features at biologically relevant length scales. This study provides a means for the quantitative exploration of the effects of topography on the performance of these devices and on biocompatibility in general.

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Citations

Sep 17, 2005·Journal of Materials Science. Materials in Medicine·Yanzhong ZhangZheng-Ming Huang
Nov 5, 2003·Experimental Neurology·Joseph M Corey, Eva L Feldman
Nov 15, 2003·Biomaterials·Hyoung-Joon JinDavid L Kaplan
Oct 18, 2002·Advanced Drug Delivery Reviews·Zaki MegeedHamidreza Ghandehari
Apr 4, 2006·Tissue Engineering·Ramalingam Murugan, Seeram Ramakrishna
Jul 9, 2010·Journal of the Royal Society, Interface·Rajeswari RavichandranSeeram Ramakrishna
Dec 21, 2006·Journal of Biomaterials Science. Polymer Edition·V HasirciE Aydin
Oct 18, 2007·Journal of Biomaterials Science. Polymer Edition·K A MoxonP I Lelkes
Dec 21, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·D SiniscalcoN Delorme
Dec 3, 2014·Journal of Neural Engineering·Mehdi JorfiJeffrey R Capadona
Dec 7, 2019·Journal of Biomedical Materials Research. Part a·Yasaman HamedaniMilana C Vasudev
Sep 17, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Mark J HendersonAlain Gibaud
Nov 12, 2002·Biomacromolecules·Hyoung-Joon JinDavid L Kaplan
Dec 13, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Ray J EmersonTerri A Camesano
Feb 14, 2006·The Journal of Physical Chemistry. B·S N Jayasinghe, A C Sullivan

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