Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler

Journal of Materials Science. Materials in Medicine
M MorraMilena Fini

Abstract

The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.

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Citations

May 20, 2016·BioMed Research International·Daniele BollatiRuggero Rodriguez Y Baena
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Giorgio IvigliaChiara Vitale-Brovarone
Aug 16, 2016·Acta Biomaterialia·Giorgio IvigliaChiara Vitale-Brovarone
Dec 20, 2017·Bio-medical Materials and Engineering·Kazuhisa FujitaAkiko Nagai
Jan 6, 2019·Journal of Functional Biomaterials·Giorgio IvigliaFrancesco Baino
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Maria SartoriMilena Fini

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Methods Mentioned

BETA
xenograft
X-ray
electron analyzer
PCR

Software Mentioned

SPSS
NRecon
Step
One
CTAn

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