Surface chemistry and serum type both determine the nanoparticle-protein corona

Journal of Proteomics
Daniela PozziAldo Laganà

Abstract

The protein corona that forms around nanoparticles in vivo is a critical factor that affects their physiological response. The potential to manipulate nanoparticle characteristics such that either proteins advantageous for delivery are recruited and/or detrimental proteins are avoided offers exciting possibilities for improving drug delivery. In this work, we used nanoliquid chromatography tandem mass spectrometry to characterize the corona of five lipid formulations after incubation in mouse and human plasma with the hope of providing data that may contribute to a better understanding of the role played by both the nanoparticle properties and the physiological environment in recruiting specific proteins to the corona. Notably, we showed that minor changes in the lipid composition might critically affect the protein corona composition demonstrating that the surface chemistry and arrangement of lipid functional groups are key players that regulate the liposome-protein interactions. Notably, we provided evidence that the protein corona that forms around liposomes is strongly affected by the physiological environment, i.e., the serum type. These results are likely to suggest that the translation of novel pharmaceutical formulation...Continue Reading

References

Feb 19, 1998·Journal of Biomedical Materials Research·M LückR H Müller
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Feb 4, 2011·Journal of the American Chemical Society·Marco P MonopoliKenneth A Dawson
Aug 27, 2011·Analytical Biochemistry·Anna Laura CapriottiAldo Laganà
Jan 24, 2012·Journal of Proteomics·Anna Laura CapriottiAldo Laganà
Jan 26, 2012·Analytical and Bioanalytical Chemistry·Anna Laura CapriottiAldo Laganà
Apr 21, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eugene MahonKenneth A Dawson
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Dec 12, 2012·ACS Nano·Zon W LaiEdouard C Nice
Sep 24, 2013·Nature Nanotechnology·Stefan TenzerRoland H Stauber
Jan 1, 2010·Pharmaceutics·Masako IchiharaHiroshi Kiwada

❮ Previous
Next ❯

Citations

Nov 27, 2015·Biochimica Et Biophysica Acta·Sara PalchettiAldo Laganà
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Nicholas J BraunKristen K Comfort
Oct 28, 2015·Journal of Proteomics·Magdalena MatysiakMarcin Kruszewski
Aug 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jie WangJessie L-S Au
Nov 9, 2016·Colloids and Surfaces. B, Biointerfaces·Claudia L OliveiraAntonio J Ribeiro
Mar 7, 2017·ACS Nano·Claudia CorboEnnio Tasciotti
Mar 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Francesca PederzoliBarbara Ruozi
Jun 6, 2019·Beilstein Journal of Nanotechnology·Katrin PartikelKlaus Langer
Feb 14, 2019·Analytical and Bioanalytical Chemistry·Anna Laura CapriottiSusy Piovesana
Oct 5, 2019·Nature Communications·Brendan P DyettCharlotte E Conn
Nov 20, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ran Chen, Jim E Riviere
Jun 20, 2018·Nature Nanotechnology·Manuel TonigoldVolker Mailänder
Jul 11, 2018·Materials·Luca GuerriniNicolas Pazos-Perez
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Enrico MiceliMarcelo Calderón
Jun 12, 2020·Frontiers in Bioengineering and Biotechnology·Riccardo Di SantoGiulio Caracciolo
Jan 31, 2017·Biomaterials Science·Claudia CorboMorteza Mahmoudi
Jan 3, 2018·Nanoscale·Rafaela García-ÁlvarezKostas Kostarelos
Feb 1, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Luca DigiacomoGiulio Caracciolo
Mar 25, 2017·Nanomaterials·Marc SangràMaria Antònia Busquets
Jun 10, 2016·Nanoscale·S PalchettiG Caracciolo
Oct 9, 2019·The Journal of Chemical Physics·Christine K Payne
Apr 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Zhan BanXiangang Hu
Feb 15, 2021·The Science of the Total Environment·Camilla Della TorreAndrea Binelli
Aug 29, 2018·Advanced Drug Delivery Reviews·Hamideh ParhizVladimir R Muzykantov
Jul 31, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min YangChangyou Zhan
Aug 8, 2021·Acta Biomaterialia·Natalia OnishchenkoElena Vodovozova
May 9, 2017·Environmental Science & Technology Letters·Jiejun GaoMaria S Sepúlveda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.