Surface confined retro Diels-Alder reaction driven by the swelling of weak polyelectrolytes

ACS Applied Materials & Interfaces
Beier LyuHongwei Ma

Abstract

Recently, the type of reactions driven by mechanical force has increased significantly; however, the number of methods for activating those mechanochemical reactions stays relatively limited. Furthermore, in situ characterization of a reaction is usually hampered by the inherent properties of conventional methods. In this study, we report a new platform that utilizes mechanical force generated by the swelling of surface tethered weak polyelectrolytes. An initiator with Diels-Alder (DA) adduct structure was applied to prepare the polyelectrolyte-carboxylated poly(OEGMA-r-HEMA), so that the force could trigger the retro DA reaction. The reaction was monitored in real time by quartz crystal microbalance and confirmed with atomic force microscopy and X-ray photoelectron spectroscopy. Compared with the conventional heating method, the swelling-induced retro DA reaction proceeded rapidly with high conversion ratio and selectivity. A 23.61 kcal/mol theoretical energy barrier supported the practicability of this retro DA reaction being triggered mechanically at ambient temperature. During swelling, the tensile force was controllable and persistent. This unique feature imparts this mechanochemical platform the potential to "freeze" an i...Continue Reading

References

Sep 19, 2000·The Journal of Organic Chemistry·J T MankaA C Friedli
Apr 4, 1997·The Journal of Organic Chemistry·Jan W. Wijnen, Jan B. F. N. Engberts
Apr 14, 2005·Chemical Reviews·J Christopher LoveGeorge M Whitesides
Mar 23, 2007·Nature·Charles R HickenbothScott R Wilson
Jan 29, 2010·Chemical Communications : Chem Comm·Hongwei MaJing Fang
Aug 28, 2010·Science·Jeremy M LenhardtStephen L Craig
Nov 27, 2010·Chemical Communications : Chem Comm·Yanxia ZhangHongwei Ma
Apr 21, 2011·Journal of the American Chemical Society·Kelly M WigginsChristopher W Bielawski
Aug 27, 2011·The Journal of Organic Chemistry·Robert C Boutelle, Brian H Northrop
Sep 17, 2011·Science·Johnathan N BrantleyChristopher W Bielawski
Nov 29, 2012·Scientific Reports·Xiumei WangHongwei Ma
Feb 8, 2013·Chemical Society Reviews·Kelly M WigginsChristopher W Bielawski
Mar 16, 2013·Macromolecular Rapid Communications·Corinna M PreussChristopher Barner-Kowollik
May 22, 2013·Journal of the American Chemical Society·Michael B Larsen, Andrew J Boydston
May 9, 2014·Science·S R WhiteR C R Gergely

❮ Previous
Next ❯

Citations

Sep 27, 2019·Chemical Communications : Chem Comm·Zi Wang, Stephen L Craig
Jan 21, 2020·ChemPlusChem·Maria Stratigaki, Robert Göstl
Aug 31, 2018·Nature Communications·Jumpei KidaHideyuki Otsuka
Jul 31, 2019·Chemical Science·Daniel MessmerA Dieter Schlüter
Oct 1, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yuanchao LiJan Genzer
Mar 21, 2017·Macromolecules·Jess M CloughRint P Sijbesma
Nov 1, 2017·Journal of the American Chemical Society·Richard Stevenson, Guillaume De Bo
Sep 10, 2020·Journal of the American Chemical Society·Isabel M KleinMaxwell J Robb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved