Surface-decorated hydroxyapatite scaffold with on-demand delivery of dexamethasone and stromal cell derived factor-1 for enhanced osteogenesis

Materials Science & Engineering. C, Materials for Biological Applications
Bingjun ZhangJie Weng

Abstract

In the process of bone regeneration, relatively early biological events including inflammatory response, angiogenesis, or stem cell homing, help the accompanying target actions of cell differentiation and calcification. Herein, we proposed a novel cell-guided tissue engineering system based on a surface-functionalized porous hydroxyapatite (HA) scaffolds with the ability to recruit cells and accelerate the differentiation of them along the osteoblastic lineage for optimizing large-sized bone defect repair. Inspired by microstructural properties of natural bone, HA scaffolds similar to the trabecular bone structure were prepared via a sugar sphere leaching technique, in which the inter-pore opening size was controllable. Dexamethasone (Dex)-loaded hydroxypropyl-β-cyclodextrin microspheres (Dex@CDMs) and stromal cell derived factor-1 (SDF-1) were uniformly immobilized onto HA surface by a cross-linked alginate coating. The resulting scaffold (SDF-1/Dex@CDMs-HA) enabled the on-demand dual-delivery of SDF-1 and Dex. In vitro cell culture assays showed that initially released SDF-1 markedly stimulated the migration of mesenchymal stem cells (MSCs) to the deep interior of the scaffold, providing abundant target cells for the function...Continue Reading

Citations

Aug 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guanghua ChenJinglong Yan
Jul 22, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Chenglong LiYandong Mu
Aug 29, 2019·Frontiers in Pharmacology·Mathie NajbergEmmanuel Garcion
Jan 19, 2021·Stem Cell Reviews and Reports·Cheng LiangWeidong Tian
Dec 21, 2020·Advances in Colloid and Interface Science·Joëlle Bizeau, Damien Mertz
Aug 27, 2021·Macromolecular Rapid Communications·Xingchen LiQuan Lin

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