Surface decorated nanoparticles as surrogate carriers for improved transport and absorption of epirubicin across the gastrointestinal tract: Pharmacokinetic and pharmacodynamic investigations

International Journal of Pharmaceutics
Mohammad TariqSushama Talegaonkar

Abstract

Epirubicin (EPI) is a P-gp substrate antracycline analogue which elicits poor oral bioavailability. In the present work, EPI loaded poly-lactide-co-glycolic acid nanoparticles (PLGA-NPs) were prepared by double emulsion approach and superficially decorated with polyethylene glycol (EPI-PNPs) and mannosamine (EPI-MNPs). Average hydrodynamic particle size of EPI-PNPs and EPI-MNPs was found 248.63 ± 12.36 and 254.23 ± 15.16 nm, respectively. Cytotoxicity studies were performed against human breast adenocarcinoma cell lines (MCF-7) confirmed the superiority of EPI-PNPs and EPI-MNPs over free epirubicin solution (EPI-S). Further, confocal laser scanning microscopy (CLSM) and flow cytometric analysis (FACS) demonstrated enhanced drug uptake through EPI-PNPs and EPI-MNPs and elucidated dominance of caveolae mediated endocytosis for NPs uptake. Cellular transport conducted on human colon adenocarcinoma cell line (Caco-2) showed 2.45 and 3.17 folds higher permeability of EPI through EPI-PNPs and EPI-MNPs when compared with EPI-S (p<0.001) while permeability of EPI was found 5.23 and 5.67 folds higher across rat ileum, respectively. Furthermore, pharmacokinetic studies demonstrated 4.7 and 5.57 folds higher oral bioavailability through E...Continue Reading

References

Jul 15, 1999·The New England Journal of Medicine·S FaderlH M Kantarjian
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y HuangN A Peppas
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T Gershanik, S Benita
Mar 3, 2005·Journal of the American Chemical Society·Yemin Liu, Theresa M Reineke
Mar 21, 2006·European Journal of Medicinal Chemistry·L-P RuanS X Qiu
May 23, 2006·Pharmaceutical Research·Sandra PeltierJean-Pierre Benoît
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·Hesham H SalmanJuan M Irache
Nov 23, 2006·International Journal of Pharmaceutics·K YonchevaJ M Irache
Jan 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Samuel K LaiJustin Hanes
Aug 31, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·YaShu YinHaiYang Hu
Sep 20, 2007·Journal of Pharmaceutical Sciences·Weilun KeYuanying Pei
Jul 10, 2008·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Camile B WoitiskiFrancisco Veiga
Jan 13, 2009·Advanced Drug Delivery Reviews·Richard A Cone
Feb 3, 2009·Colloids and Surfaces. B, Biointerfaces·Hui-zhu ZhangQi-qing Zhang
Aug 25, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·E RogerJ-P Benoit
Mar 17, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Boitumelo SemeteHulda S Swai
Mar 30, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·M AgüerosJ M Irache
Jan 10, 2012·International Journal of Pharmaceutics·Boitumelo SemeteHulda S Swai
Jun 12, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Michael L EtheridgeJeffrey McCullough
Aug 9, 2012·Molecular Pharmaceutics·Sanyog JainAshish K Agrawal
May 9, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Garima JoshiKrutika Sawant
Jun 3, 2014·International Journal of Pharmaceutics·Linlin WangShirui Mao
Dec 5, 2014·International Journal of Nanomedicine·Xingwang ZhangBaojian Wu
Mar 15, 2015·Colloids and Surfaces. B, Biointerfaces·Mohammad TariqSushama Talegaonkar
May 3, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Richard A GravesTarun K Mandal

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Citations

Oct 31, 2016·Advanced Drug Delivery Reviews·Zhong-Cheng MoGuang-Hui Yi
Apr 24, 2019·The Journal of Pharmacology and Experimental Therapeutics·G KaurM N V Ravi Kumar
May 16, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Niyaz AhmadFarhan Jalees Ahmad

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