Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy.

APL Bioengineering
Aleena Mary CherianDeepthy Menon

Abstract

Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited through the use of the current clinical drug-eluting stent which releases antiproliferative drugs, problems of late-stent thrombosis remain a concern due to polymer hypersensitivity and delayed re-endothelialization. Thus, the field of coronary stenting demands devices having enhanced compatibility and effectiveness to endothelial cells. Nanotechnology allows for efficient modulation of surface roughness, chemistry, feature size, and drug/biologics loading, to attain the desired biological response. Hence, surface topographical modification at the nanoscale is a plausible strategy to improve stent performance by utilizing novel design schemes that incorporate nanofeatures via the use of nanostructures, particles, or fibers, with or without the use of drugs/biologics. The main intent of this review is to deliberate on the impact of nanotechnology approaches for stent design and development and the recent advancements in this field on vascular stent performance.

References

Jan 31, 1998·Cardiovascular Research·D Brieger, E Topol
Sep 23, 2000·Nature·A J Lusis
Aug 22, 2001·Circulation·S WindeckerUNKNOWN Working Group on Novel Surface Coating of Biomedical Devices (SCOL)
Apr 18, 2003·Biomaterials·N HuangY Leng
Oct 3, 2003·The New England Journal of Medicine·Andrew R Marks
Oct 9, 2003·Journal of the American Chemical Society·Zhengrong R TianHuifang Xu
Oct 18, 2003·Journal of Interventional Cardiology·Martin UnverdorbenChristian Vallbracht
Oct 23, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Heinrich WienekeRaimund Erbel
Dec 25, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Marc KollumChristoph Hehrlein
Mar 1, 2005·Angewandte Chemie·Jan M MacákPatrik Schmuki
Sep 15, 2005·JAMA : the Journal of the American Medical Association·Gregg W StoneUNKNOWN TAXUS V Investigators
Dec 14, 2005·Journal of Biomedical Materials Research. Part a·Hung-I YehCheng-Ho Tsai
Feb 8, 2006·The American Journal of Cardiology·Cheol Whan LeeSeung-Jung Park
Aug 4, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miechel L T ZweersJan Feijen
Nov 17, 2006·Journal of Interventional Cardiology·Suzan CommandeurWim J van der Giessen
Dec 6, 2006·Journal of Vascular Surgery·Jeffrey M Caves, Elliot L Chaikof
Dec 26, 2006·Biomaterials·Gopinath ManiC Mauli Agrawal
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
May 24, 2007·Tissue Engineering·Saba ChoudharyThomas J Webster
Aug 28, 2007·International Journal of Nanomedicine·Saba ChoudharyThomas J Webster
Feb 7, 2008·Nano Letters·Karla S BrammerSungho Jin
Mar 14, 2008·Toxicologic Pathology·Michael N HelmusDavid Cebon
Jun 26, 2008·JAMA : the Journal of the American Medical Association·David J MalenkaJonathan S Skinner
Jan 1, 2007·Recent Patents on Nanotechnology·Aleksandra B DjurisicWai K Chan
Feb 3, 2009·Experimental and Molecular Pathology·Rajesh Singh, James W Lillard
Feb 24, 2009·Biomaterials·Malgorzata S CartieraW Mark Saltzman
Mar 14, 2009·Journal of Interventional Cardiology·Lakshmana PendyalaNicolas Chronos
Jun 3, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yair LevyAbraham J Domb

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