Surface engineering of poly(dimethylsiloxane) microfluidic devices using transition metal sol-gel chemistry

Langmuir : the ACS Journal of Surfaces and Colloids
Gregory T Roman, Christopher T Culbertson

Abstract

We report the coating of poly(dimethylsiloxane) (PDMS) microchannels using transition metal sol-gel chemistry and the subsequent characterization of the coatings. The channels were created using soft polymer lithography, and three metal alkoxide sol-gel precursors were investigated, titanium isopropoxide, zirconium isopropoxide, and vanadium triisobutoxide oxide. The metal alkoxides were diffused into the sidewalls of a PDMS channel and subsequently hydrolyzed using water vapor. This procedure resulted in the formation of durable metal oxide surfaces of titania, zirconia, or vanadia. The resulting surfaces were characterized using contact angle, X-ray photoelectron spectroscopy (XPS), Raman, transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), and electroosmotic mobility (EOM) measurements. All of the metal oxide-modified PDMS surfaces were significantly more hydrophilic than native PDMS. Contact angles for the coatings were 90 degrees for PDMS-ZrO2, 61 degrees for PDMS-TiO2, and 19 degrees for PDMS-vanadia. XPS showed the presence of titania, zirconia, and vanadia on the PDMS surface. XPS spectra also showed no chemical modification of the PDMS after the in situ deposition ...Continue Reading

References

Sep 7, 1990·Journal of Chromatography·J K Towns, F E Regnier
Jul 15, 1994·Journal of Chromatography. B, Biomedical Applications·P TsaiC S Lee
Jan 14, 2000·Electrophoresis·J C McDonaldG M Whitesides
Jun 14, 2001·Analytical Chemistry·N GottschlichJ M Ramsey
Jul 2, 2002·Analytical Chemistry·Pierre-Alain AurouxAndreas Manz
Mar 8, 2003·Analytical Chemistry·Andrew M LeachRichard N Zare
May 2, 2003·Analytical Chemistry·Jörg LahannRobert Langer
Nov 13, 2003·Electrophoresis·Honest MakambaJong Hoon Hahn
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·R J DekkerC A Van Blitterswijk
Dec 1, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Ashish A Vaidya, Michael L Norton
Jun 29, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Jana StriovaMaryanne M Collinson
Dec 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Daniel P BrennanScott R J Oliver
Dec 1, 1998·Analytical Chemistry·D C DuffyG M Whitesides

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Citations

Apr 10, 2012·Annals of Biomedical Engineering·Jack D WangMohamed ElSayed
Apr 17, 1980·Biochimica Et Biophysica Acta·H OtsukaM Goto
Mar 29, 2008·Lab on a Chip·Adam R AbateDavid A Weitz
Jul 17, 2009·Lab on a Chip·Keil J RegehrDavid J Beebe
Jul 3, 2010·Lab on a Chip·Peter B LillehojChih-Ming Ho
Jan 27, 2011·Lab on a Chip·Adam F ChrimesKourosh Kalantar-Zadeh
Oct 4, 2012·Lab on a Chip·Asif RiazLuke P Lee
May 15, 2013·Lab on a Chip·Mark D BorysiakJonathan D Posner
Sep 3, 2009·Journal of Biomaterials Science. Polymer Edition·Mini NamdeoS Kakkar
Nov 4, 2010·Biomicrofluidics·Craig Priest
Sep 17, 2013·Biomedical Microdevices·Caterina ZilioMarcella Chiari
Apr 2, 2010·Microfluidics and Nanofluidics·Ieong Wong, Chih-Ming Ho
Feb 2, 2016·Environmental Science & Technology·Zhangxin WangShihong Lin
Mar 19, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Dimitrios N SoulasKyriaki G Papadokostaki
Dec 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Bat-El Shani PinchasikHelmuth Möhwald
Mar 7, 2007·Electrophoresis·Jonathan A VickersCharles S Henry
Dec 7, 2007·Electrophoresis·Youyuan PengMyriam Taverna
Apr 12, 2014·Electrophoresis·Richard Piffer Soares de CamposJosé Alberto Fracassi da Silva
Dec 30, 2009·Electrophoresis·Jinwen ZhouNicolas Hans Voelcker
Oct 15, 2014·Journal of Colloid and Interface Science·Neus VilanovaCarlos Rodríguez-Abreu
Apr 16, 2016·ACS Applied Materials & Interfaces·Chun-Yi Li, Ying-Chih Liao
Oct 31, 2020·Biotechnology and Bioengineering·Fei ZhangYecheng Zhang
Jan 7, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Ana L CordeiroCarsten Werner
Jan 1, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Dan WangJ Hugh Horton
Apr 2, 2010·ACS Applied Materials & Interfaces·T Joseph Dennes, Jeffrey Schwartz
Jul 26, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·J-B OrhanM A M Gijs

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