PMID: 109526May 1, 1979

Surface expression and synthesis of I-A and I-E/C encoded molecules by B lymphocytes and Ig-secreting cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
E S Vitetta, R G Cook


Splenocytes from recombinant mice were radiolabeled before or after deletion of subpopulations by cytotoxic anterisera (+C) directed against I-A, I-E/C, IgM, or Ig. Examination of the lysates of the surviving cells by immunoprecipitation demonstrated that 1) virtually all I-A and I-E/C molecules are co-expressed and synthesized by Ig+, IgM+ lymphocytes, 2) I-A, I-E/C, and IgM molecules are present on many of the cells secreting IgM and IgG, and 3) populations of Ig-bearing or Ig-secreting cells that lack detectable I-A and I-E/C antigens can be identified in spleen cell populations. The co-expression of I-A and I-E/C on most cells of the B cell lineage is discussed in terms of our present concepts of Ir gene control of immune responses.

Related Concepts

Antibody-Secreting Cells
Surface Antigens
Hemolytic Complement
Immune Sera
Immunoglobulin mu-Chains
Receptors, Antigen, B-Cell

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