Surface expression of Kv1 voltage-gated K+ channels is governed by a C-terminal motif

Trends in Cardiovascular Medicine
E S Levitan, K Takimoto

Abstract

The normal rhythmic beating of the heart relies on tight control of expression of voltage-gated ion channels in the plasma membrane of cardiac myocytes. Recently, a conserved motif was identified near the C-terminus of Kv1 voltage-gated K+ channels that is required for efficient processing and surface expression. Furthermore, variations in the motif account for differences among normal channels in localization and the requirement for auxiliary subunits for robust expression. Thus, this motif is a key regulator of cell surface expression of Kv1 family K+ channels.

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Citations

Aug 5, 2008·Brain Cell Biology·Viviana GradinaruKarl Deisseroth
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Victoria P Korovkina, Sarah K England
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·L N ManganasJ S Trimmer
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Kailash N Pandey
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Olga SokolovaNikolaus Grigorieff
Sep 8, 2010·Current Opinion in Biotechnology·Kailash N Pandey
Feb 13, 2019·International Journal of Molecular Sciences·Jesusa CaperaAntonio Felipe
Mar 9, 2007·American Journal of Physiology. Cell Physiology·Lian ZhangJeffrey R Martens
May 21, 2019·Critical Reviews in Biochemistry and Molecular Biology·Surbhi Sharma, Martin R Schiller

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