Surface grafting of biocompatible phospholipid polymer MPC provides wear resistance of tibial polyethylene insert in artificial knee joints

Osteoarthritis and Cartilage
Toru MoroHiroshi Kawaguchi

Abstract

Aseptic loosening of artificial knee joints induced by wear particles from a tibial polyethylene (PE) insert is a serious problem limiting their longevity. This study investigated the effects of grafting with our original biocompatible phospholipid polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) on the insert surface. The hydrophilicity of the PE surface was determined by the contact angle of a water droplet, and the friction torque was measured against a cobalt-chromium alloy component. The wear amount was compared among PE inserts with or without cross-linking and MPC grafting during 5x10(6) cycles of loading in a knee joint simulator. The surfaces of the insert and the wear particles in the lubricant were subjected to electron and laser microscopic analyses. The mechanical properties of the inserts were evaluated by the small punch test. The MPC grafting increased hydrophilicity and decreased friction torque. In the simulator experiment, the wear of the tibial insert was significantly suppressed in the cross-linked PE (CLPE) insert, and even more dramatically decreased in the MPC-grafted CLPE insert, as compared to that in the non-cross-linked PE insert. Surface analyses confirmed the wear resistance by the cross-link...Continue Reading

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Citations

Oct 25, 2011·Journal of Materials Science. Materials in Medicine·Jing Jing Wang, Fang Liu
May 9, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Toru MoroYoshio Takatori
Oct 25, 2016·Advanced Materials Interfaces·Chia-Chih ChangTodd Emrick
Nov 20, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Toru MoroHiroshi Kawaguchi
Jun 4, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lingyun LiuQingsheng Liu
Mar 7, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kenichi WatanabeKazuhiko Ishihara
Jun 4, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Seido YarimitsuTeruo Murakami
Aug 4, 2015·Chemical Communications : Chem Comm·Anusha Garapaty, Julie A Champion
Nov 18, 2015·Advanced Healthcare Materials·Jasper van WeerdPascal Jonkheijm
Feb 1, 2019·Journal of Biomedical Materials Research. Part a·Kazuhiko Ishihara
Feb 24, 2017·Science and Technology of Advanced Materials·Subir Ghosh, Sylvester Abanteriba
Dec 29, 2020·The Journal of Vascular Access·Shuji KariyaNoboru Tanigawa

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