Surface-Layer Protein-Enhanced Immunotherapy Based on Cell Membrane-Coated Nanoparticles for the Effective Inhibition of Tumor Growth and Metastasis

ACS Applied Materials & Interfaces
Min WuGuping Tang

Abstract

Chemo-immunotherapy is an important tool to overcome tumor immune suppression in cancer immunotherapy. Herein, we report a surface-layer (S-layer) protein-enhanced immunotherapy strategy based on cell membrane-coated S-CM-HPAD nanoparticles for the effective malignant tumor therapy and metastasis inhibition. The S-CM-HPAD NPs could effectively deliver the tumor antigen, DOX, and immunoadjuvant to the homotypic tumor by the homotypic targeting ability of the coated cell membrane. In addition to its ability to induce tumor cell death, the loaded DOX could enhance the immunotherapy response by inhibition of myeloid-derived suppressor cells (MDSCs). Because of the intrinsic adjuvant property and capability to surface display epitopes and proteins, the S-layers localized on the surface of S-CM-HPAD NPs potentiated the immune response to the antigen. The results confirmed that the protective immunity against tumor occurrence was promoted effectively by prompting proliferation of lymphocytes and secretion of cytokine caused by the tumor-associated antigen and adjuvant. The excellent combinational therapeutic effects on the inhibition of tumor growth and metastasis in the melanoma tumor models demonstrated that the S-layer-enhanced imm...Continue Reading

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Citations

Feb 27, 2020·Nanomedicine·Shuaijun ZouLiming Zhang
Jun 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuzhen LiXin Ding
Apr 17, 2020·Angewandte Chemie·Shuangqian YanXiaogang Liu
Feb 1, 2020·Acta Biomaterialia·Cheng-Hui XuCui-Yun Yu
Feb 16, 2021·Advanced Healthcare Materials·Faisal RazaQiu Mingfeng
Feb 27, 2021·Clinical and Translational Medicine·Minghai ZhangYu Wang
Jun 18, 2021·Nano-micro Letters·Shruti Rawal, Mayur Patel
Jun 18, 2021·Nano-micro Letters·Weiwei MuNa Zhang
Aug 10, 2021·Advanced Drug Delivery Reviews·Melgious Jin Yan AngXiaogang Liu
Jan 15, 2020·Journal of the American Chemical Society·Mram Z AlyamiNiveen M Khashab
Aug 23, 2021·Biomarker Research·Lei DouHaifeng Dong
Oct 5, 2021·Chemical Society Reviews·Qi-Wen ChenXian-Zheng Zhang

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