Surface light chain phenotype in indolent lymphomas: lack of prognostic significance

American Journal of Hematology
L A VanderMolenD L Longo

Abstract

The indolent follicular and diffuse lymphomas are neoplasms of B-cell origin. In several other B-cell neoplastic disorders, including multiple myeloma, hairy cell leukemia, and chronic lymphocytic leukemia, the light chain isotype of the surface immunoglobulin has been reported to have prognostic significance. Patients with tumors expressing lambda light chains usually fare more poorly than those with kappa light chain-bearing tumours. We analyzed the clinical data and immunologic phenotype of 101 patients with indolent lymphoma. Eighty-nine of the 101 patients demonstrated surface immunoglobulin of only one light chain type (kappa-47, lambda-42). Patients in both groups were matched for known prognostic factors. There were no significant differences in disease-free survival or overall survival between the two groups or within histologic subtypes. These results indicate that the immunologic light chain phenotype in indolent lymphoma, unlike other B-cell neoplasms, is not a prognostic indicator of survival.

References

Jan 1, 1979·Annals of Internal Medicine·C S Portlock, S A Rosenberg
Jan 1, 1975·Journal of the National Cancer Institute·J H LeechR D Collins
Jun 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinD O Dixon
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J GallagherT A Lister
May 1, 1984·Annals of Internal Medicine·D L LongoV T DeVita
Jun 1, 1982·American Journal of Hematology·H M GolombJ Vardiman

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Citations

Apr 28, 2007·Leukemia Research·Evgeny AronsRobert J Kreitman
Mar 1, 1996·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·J WangM Stetler-Stevenson
Aug 1, 1992·American Journal of Hematology·N M AlmasriR C Braylan

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