PMID: 7013967Mar 15, 1981Paper

Surface marker and histopathologic correlation with long-term survival in advanced large-cell non-Hodgkin's lymphoma

Cancer
R A RuddersR A DeLellis

Abstract

Since 1974, a group of consecutive adult patients with non-Hodgkin's lymphoma have been prospectively analyzed for tumor-surface membrane-marker phenotype and histopathologic correlation with response to treatment and survival. The results are reported in a subset of 35 patients with advanced (Stages III-IV) large-cell variants, most of whom would be classified by Rappaport criteria as histiocytic. An attempt has been made to define those marker characteristics that will identify long-term survivors in this diverse group who remain in continuous disease-free remission. There were ten patients with complete remissions with intensive treatment. The most common subgroup within the complete responders were patients with cells that were nonexpressive (null) and were classified by Lukes-Collins criteria as the large, noncleaved follicular center cell variant. Currently there are seven patients remaining in complete remission, five of whom have been in continuous disease-free remission for more than two years (total survival 34+-42+ months) following cessation of all treatment. Of those five, four were in the null group and four were classified as large non-cleaved. The actuarial survival curve for all null patients is characterized b...Continue Reading

References

Dec 21, 1978·The New England Journal of Medicine·J A StrauchenC W Berard
Jan 1, 1978·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·C W BerardK Nanba
Mar 1, 1976·Journal of the National Cancer Institute·J C BrouetM Seligmann
Jul 1, 1972·The Journal of Experimental Medicine·H B Dickler, H G Kunkel
Oct 1, 1974·Cancer·R J Lukes, R D Collins
Aug 7, 1980·The New England Journal of Medicine·R WarnkeR Levy
Feb 1, 1980·The American Journal of Medicine·A C AisenbergN L Harris

❮ Previous
Next ❯

Citations

Dec 29, 1983·The New England Journal of Medicine·A ArnoldS J Korsmeyer
Jan 1, 1996·Cancer Investigation·A S Freedman
Nov 1, 1983·Histopathology·G PallesenS Schifter
Nov 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·B ChristenssonP Biberfeld
Nov 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·C LindemalmP Biberfeld
Jan 1, 1983·Hospital Practice·R A Rudders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.