Surface mobility of molecular glasses and its importance in physical stability

Advanced Drug Delivery Reviews
Lian Yu

Abstract

Amorphous molecular materials (molecular glasses) are useful for drug delivery, bio-preservation and organic electronics. A central issue in developing amorphous materials is the stability against crystallization and other transformations that can compromise material performance. We review recent progress in understanding the stability of molecular glasses, particularly the role for surface mobility. Surface diffusion in molecular glasses can be vastly faster than bulk diffusion. This high surface mobility enables fast crystal growth on the free surface. In this process, surface crystals grow upward and laterally, with the lateral growth rate being roughly proportional to surface diffusivity. Surface mobility also influences bulk crystal growth as the process can create fracture and free surfaces. During vapor deposition, surface mobility allows efficient equilibration of newly deposited molecules, producing low-energy, high-density glasses that are equivalent to liquid-cooled glasses aged for thousands of years. Free surfaces can accelerate chemical degradation of proteins. Measures for inhibiting surface-facilitated transformations include minimizing free surfaces, applying surface coatings, and preventing fracture.

References

Aug 1, 1984·Cryobiology·G M FahyH T Meryman
Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Apr 29, 1998·Annual Review of Physiology·J H CroweL M Crowe
Feb 9, 2002·Journal of Pharmaceutical Sciences·Henry R CostantinoMark A Tracy
Apr 24, 2003·Journal of the American Chemical Society·Richard C BellJames P Cowin
Feb 14, 2006·The Journal of Physical Chemistry. B·Marie K MapesM D Ediger
Aug 24, 2006·Pharmaceutical Research·Tian Wu, Lian Yu
Dec 13, 2006·Science·Stephen F SwallenSushil Satija
Apr 3, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Tian WuLian Yu
Aug 28, 2007·Journal of Pharmaceutical Sciences·Chandan Bhugra, Michael J Pikal
Jan 22, 2008·The Journal of Chemical Physics·M D EdigerLian Yu
Jan 30, 2008·Journal of Pharmaceutical Sciences·Chandan BhugraMichael J Pikal
Dec 24, 2008·The Journal of Chemical Physics·Jacob D Stevenson, Peter G Wolynes
May 13, 2009·Molecular Pharmaceutics·Lei ZhuLian Yu
Jun 6, 2009·Journal of Pharmaceutical Sciences·Sisir Bhattacharya, Raj Suryanarayanan
Apr 24, 2010·Pharmaceutical Research·Lei ZhuTian Wu
Dec 21, 2010·The Journal of Physical Chemistry. B·Kevin J DawsonM D Ediger
Dec 22, 2010·The Journal of Physical Chemistry. a·Jacob D Stevenson, Peter G Wolynes
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ye SunLian Yu
May 18, 2011·Journal of the American Chemical Society·Keewook PaengM D Ediger
May 24, 2011·The Journal of Chemical Physics·Rohit MalsheJ J de Pablo
Jul 21, 2011·Physical Review Letters·L ZhuL Yu
Oct 7, 2011·Journal of Pharmaceutical Sciences·Ken K Qian, Robin H Bogner
May 29, 2012·Pharmaceutical Research·Zelalem AyenewGuy Van den Mooter
Sep 25, 2012·The Journal of Chemical Physics·Christiane Caroli, Anaël Lemaître
Dec 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S CapaccioliD Prevosto
Jul 9, 2013·The Journal of Physical Chemistry. a·Caleb W Brian, Lian Yu
Sep 10, 2013·International Journal of Pharmaceutics·Petra A PriemelClare J Strachan
Feb 12, 2014·The Journal of Chemical Physics·Caleb W BrianLian Yu
Jun 13, 2014·The Journal of Physical Chemistry. B·Mariko HasebeLian Yu
Jul 17, 2014·The Journal of Chemical Physics·Amir Haji-Akbari, Pablo G Debenedetti
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shakeel S DalalM D Ediger
Apr 24, 2015·Journal of Pharmaceutical Sciences·Maxx Capece, Rajesh Davé
Jul 15, 2015·The Journal of Physical Chemistry. B·C Travis PowellLian Yu
May 15, 2014·The Journal of Physical Chemistry Letters·Daniele MusumeciLian Yu
Sep 20, 2012·The Journal of Physical Chemistry Letters·Keewook PaengM D Ediger
Sep 4, 2015·The Journal of Chemical Physics·Katherine R WhitakerM D Ediger

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Citations

Aug 18, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Georgia KastenKorbinian Löbmann
Feb 22, 2017·The Journal of Physical Chemistry. B·Audrey LaventureM D Ediger
Apr 22, 2017·The Journal of Physical Chemistry. B·Benjamin SchamméGérard Coquerel
Dec 30, 2017·Physical Review Letters·Gang SunPeter Harrowell
Sep 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Camille BishopM D Ediger
Dec 10, 2019·Expert Opinion on Drug Delivery·Nivedita ShettyQi Tony Zhou
Sep 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Aixi ZhangZahra Fakhraai
Dec 10, 2017·The Journal of Chemical Physics·M D Ediger
Dec 15, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jean-Michel Nunzi, Olivier Lebel
Jun 11, 2020·Pharmaceutics·Jacob BannowThomas Rades
Jun 3, 2017·The Journal of Chemical Physics·M TylinskiM D Ediger
Nov 11, 2019·The Journal of Chemical Physics·Birte RiechersRanko Richert
Feb 10, 2017·The Journal of Chemical Physics·Jaritza GómezM D Ediger
Jan 7, 2018·Pharmaceutical Research·Rattavut TeerakapibalLian Yu
Nov 5, 2019·International Journal of Pharmaceutics·Wangding LuMingshi Yang
Feb 21, 2021·The Journal of Chemical Physics·Jaroslav BartákLian Yu
Mar 25, 2019·Journal of Pharmaceutical Sciences·Mansour LatrecheFlorence Danède
Jun 22, 2021·ACS Nano·Debaditya ChatterjeePaul M Voyles
Aug 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yi JinZahra Fakhraai
Aug 7, 2021·The Journal of Physical Chemistry. B·Mark D EdigerPeter G Wolynes
Jul 21, 2017·The Journal of Physical Chemistry. B·Quentin VielEric Dargent
Jun 11, 2019·The Journal of Physical Chemistry Letters·Camille BishopMark D Ediger
May 9, 2018·Molecular Pharmaceutics·Justyna Knapik-KowalczukMarian Paluch
Aug 14, 2020·The Journal of Physical Chemistry Letters·Kushal Bagchi, M D Ediger
Aug 29, 2021·Pharmaceutics·Xin YaoLian Yu
Oct 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Marie E FioriM D Ediger

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