Surface mobility of postsynaptic AMPARs tunes synaptic transmission.

Science
Martin HeineDaniel Choquet

Abstract

AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.

References

Mar 1, 1996·Trends in Neurosciences·M V Jones, G L Westbrook
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·X XieT W Berger
Jul 1, 1997·Biomaterials·J S Rees, P H Jacobsen
Jun 16, 1999·Journal of Neurophysiology·G O HjelmstadR C Malenka
Mar 7, 2001·The Journal of Physiology·E Hanse, B Gustafsson
Jun 19, 2001·Trends in Neurosciences·E S Fortune, G J Rose
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Jun 7, 2002·Nature·Aren J Borgdorff, Daniel Choquet
Nov 5, 2002·Biophysical Journal·Kevin M FranksTerrence J Sejnowski
Apr 3, 2003·The European Journal of Neuroscience·Julian GrosskreutzJohannes Bufler
Sep 13, 2003·The EMBO Journal·Catherine TardinDaniel Choquet
Dec 21, 2005·Neuron·Hillel AdesnikPamela M England
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael C AshbyJeremy M Henley
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean-Claude BéïqueRichard L Huganir
Jul 20, 2007·Nature Reviews. Neuroscience·John E LismanRichard W Tsien
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurent GrocLaurent Cognet

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Citations

Sep 21, 2013·Molecules and Cells·Inna V NechipurenkoPiali Sengupta
Jun 13, 2009·Annals of Biomedical Engineering·Thomas Pons, Hedi Mattoussi
Jul 10, 2009·Bulletin of Mathematical Biology·Hamid Reza Noori, Willi Jäger
Mar 1, 2012·Journal of Molecular Neuroscience : MN·Juan ChengChen Zhang
Aug 1, 2008·Neuron Glia Biology·Renato Frischknecht, Constanze I Seidenbecher
May 7, 2011·Journal of the American Chemical Society·Christian GrunwaldRobert Tampé
Mar 6, 2013·Nano Letters·Cécile LeducBrahim Lounis
May 13, 2009·Acta Pharmacologica Sinica·Robert A NeffDarwin K Berg
Dec 28, 2010·Nature Chemical Biology·Matthieu SainlosBarbara Imperiali
Apr 1, 2010·Nature Methods·Fabien PinaudMaxime Dahan
Jun 2, 2009·Nature Neuroscience·Renato FrischknechtEckart D Gundelfinger
Jun 27, 2013·Nature Neuroscience·Marta Maglione, Stephan J Sigrist
Mar 5, 2011·Nature Protocols·Graham C R Ellis-Davies
Jan 21, 2009·Nature Reviews. Neuroscience·Wei Feng, Mingjie Zhang
Aug 11, 2010·Chemical Society Reviews·Pavel ZrazhevskiyXiaohu Gao
May 10, 2008·Médecine sciences : M/S·Daniel Choquet, Brahim Lounis
Dec 3, 2009·Médecine sciences : M/S·Laurent Groc, Daniel Choquet
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lenka MikasovaOlivier J Manzoni
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Louisa A ChristieAnis Contractor
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A PattersonRyohei Yasuda
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wei LuRoger A Nicoll
Sep 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Grégory GauvainJean Christophe Poncer
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Katalin CzöndörOlivier R Thoumine
Oct 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nathanael HozeDavid Holcman
Sep 18, 2013·The Journal of Cell Biology·Hirohito NishimuraAkihiro Kusumi
Oct 30, 2013·The Journal of Cell Biology·Nathalia Vitureira, Yukiko Goda
May 1, 2012·Brain : a Journal of Neurology·Lenka MikasovaLaurent Groc
Nov 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emile G BruneauMohammed Akaaboune
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew J MacDougall, Alan Fine
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Leonid P Savtchenko, Dmitri A Rusakov
Dec 16, 2011·The Journal of Pharmacology and Experimental Therapeutics·Xueliang FanEllen J Hess
Oct 7, 2011·Journal of Neurophysiology·Richard Hallworth, Michael G Nichols
Jan 29, 2010·Journal of Neurophysiology·Soham Chanda, Matthew A Xu-Friedman
Feb 9, 2012·Physiology·Pablo Ariel, Timothy A Ryan
Oct 9, 2012·The Journal of Clinical Investigation·Gregory PorrasErwan Bezard
May 1, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ruth L Stornetta, J Julius Zhu
Oct 1, 2011·Molecular Brain·Zahid Padamsey, Nigel J Emptage

❮ Previous
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