Surface modification and evaluation of bacterial cellulose for drug delivery

International Journal of Biological Macromolecules
Munair BadshahTaous Khan

Abstract

The current study was designed to prepare surface modified BC matrices loaded with model drugs selected on the basis of their aqueous solubility, i.e., poorly water soluble famotidine and highly water soluble tizanidine. Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA) confirmed the successful drug loading and thermal stability of the BC matrices. In-vitro dissolution studies using USP type-II dissolution apparatus showed that most of the drug was released in 0.5-3h from famotidine loaded matrices and in 0.25-0.5h from tizanidine loaded matrices. The chemical structure, concentration of the loaded drug, concentration of the surface modifier, and pre- and post-drug loading modifications altered the physicochemical properties of BC matrices, which in turn affected the drug release behavior. In general, surface modification of the BC matrices enhanced the drug release retardant properties in pre-modification drug loading. Surface modification was found to be effective for controlling the drug release properties of BC. Therefore, these modified BC matrices have the potential for applications in modified drug delivery systems.

Citations

Oct 13, 2019·Current Pharmaceutical Design·Hanif UllahTaous Khan
Feb 29, 2020·Nanomaterials·Soon Mo Choi, Eun Joo Shin
Jun 27, 2020·Journal of Biomaterials Science. Polymer Edition·Chutima JantaratSuthon Srivaro
Aug 8, 2020·Journal of Tissue Engineering and Regenerative Medicine·Muhammad Umar Aslam KhanSaira Aftab
Dec 22, 2020·Frontiers in Bioengineering and Biotechnology·Munair BadshahTaous Khan
Nov 16, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yaser AlkhatibDagmar Fischer
Oct 5, 2021·Expert Opinion on Drug Delivery·Munira MominAbdelwahab Omri

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