Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold

Biomaterials
C CrowleySam M Janes

Abstract

Polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) is a versatile nanocomposite biomaterial with growing applications as a bioscaffold for tissue engineering. Integration of synthetic implants with host tissue can be problematic but could be improved by topographical modifications. We describe optimization of POSS-PCU by dispersion of porogens (sodium bicarbonate (NaHCO3), sodium chloride (NaCl) and sucrose) onto the material surface, with the principle aim of increasing surface porosity, thus providing additional opportunities for improved cellular and vascular ingrowth. We assess the effect of the porogens on the material's mechanical strength, surface chemistry, wettability and cytocompatibilty. Surface porosity was characterized by scanning electron microscopy (SEM). There was no alteration in surface chemistry and wettability and only modest changes in mechanical properties were detected. The size of porogens correlated well with the porosity of the construct produced and larger porogens improved interconnectivity of spaces within constructs. Using primary human bronchial epithelial cells (HBECs) we demonstrate moderate in vitro cytocompatibility for all surface modifications; however, larger por...Continue Reading

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Citations

Feb 4, 2016·American Journal of Respiratory and Critical Care Medicine·Colin R ButlerSam M Janes
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Feb 24, 2017·Journal of Tissue Engineering·Rhea SaksenaAchala de Mel
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Jun 11, 2019·Biomaterials Science·Yuanhao ZhangWeian Zhang
Mar 23, 2017·Journal of Extracellular Vesicles·ZhengQiang YuanSam M Janes
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Aug 13, 2018·ACS Biomaterials Science & Engineering·Zhongchun ChenXia Zhao

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Methods Mentioned

BETA
coronary artery bypass
scanning electron microscopy
scanning
biopsy

Software Mentioned

Joel
NanoZoomer Digital Pathology
POSS
GraphPad prism
Volocity
Bluehill
PCU

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