Surface Modification of Gd Nanoparticles with pH-Responsive Block Copolymers for Use As Smart MRI Contrast Agents

ACS Applied Materials & Interfaces
Liping ZhuStephen G Boyes

Abstract

Despite recent advances in the understanding of fundamental cancer biology, cancer remains the second most common cause of death in the United States. One of the primary factors indicative of high cancer morbidity and mortality and aggressive cancer phenotypes is tumors with a low extracellular pH (pHe). Thus, the ability to measure tumor pHe in vivo using noninvasive and accurate techniques that also provide high spatiotemporal resolution has become increasingly important and is of great interest to researchers and clinicians. In an effort to develop a pH-responsive magnetic resonance imaging (MRI) contrast agent (CA) that has the potential to be used to measure tumor pHe, well-defined pH-responsive polymers, synthesized via reversible addition-fragmentation chain transfer polymerization, were attached to the surface of gadolinium-based nanoparticles (GdNPs) via a "grafting to" method after reduction of the thiocarbonylthio end groups. The successful modification of the GdNPs was verified by transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and dynamic light scattering. The performance of the pH-responsive polymer modified GdNPs was then evaluated for potential use as smart M...Continue Reading

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Citations

Apr 4, 2017·Biomacromolecules·Carlos CaroManuel Pernia Leal
Jul 10, 2019·Chemical Communications : Chem Comm·Juan PellicoJason J Davis
May 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi CaoRenjun Pei
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Jan 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yilin HeRenjun Pei
Feb 14, 2018·Biomacromolecules·Charmainne CrujeElizabeth R Gillies

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