Surface modification of nonviral nanocarriers for enhanced gene delivery

Nanomedicine
Charles FortierGregory De Crescenzo

Abstract

Biomedical nanotechnology has given a new lease of life to gene therapy with the ever-developing and ever-diversifying nonviral gene delivery nanocarriers. These are designed to pass a series of barriers in order to bring their nucleic acid cargo to the right subcellular location of particular cells. For a given application, each barrier has its dedicated strategy, which translates into a physicochemical, biological and temporal identity of the nanocarrier surface. Different strategies have thus been explored to implement adequate surface identities on nanocarriers over time for systemic delivery. In that context, this review will mainly focus on organic nanocarriers, for which these strategies will be described and discussed.

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Citations

Apr 16, 2014·BJU International·Michael MaddoxBenjamin R Lee
Apr 17, 2015·Biomacromolecules·Charles FortierGregory De Crescenzo
May 26, 2015·International Journal of Pharmaceutics·Ming ChenXuli Feng
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ming ChenXuli Feng
Apr 18, 2016·Journal of Biotechnology·Laurence DelafosseYves Durocher
Sep 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lies A L FliervoetTina Vermonden

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Methods Mentioned

BETA
transfection
Confocal microscopy
xenograft
nuclear translocation

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