Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding.

Langmuir : the ACS Journal of Surfaces and Colloids
Rahul P BagweWeihong Tan

Abstract

In this article, a systematic study of the design and development of surface-modification schemes for silica nanoparticles is presented. The nanoparticle surface design involves an optimum balance of the use of inert and active surface functional groups to achieve minimal nanoparticle aggregation and reduce nanoparticle nonspecific binding. Silica nanoparticles were prepared in a water-in-oil microemulsion and subsequently surface modified via cohydrolysis with tetraethyl orthosilicate (TEOS) and various organosilane reagents. Nanoparticles with different functional groups, including carboxylate, amine, amine/phosphonate, poly(ethylene glycol), octadecyl, and carboxylate/octadecyl groups, were produced. Aggregation studies using SEM, dynamic light scattering, and zeta potential analysis indicate that severe aggregation among amine-modified silica nanoparticles can be reduced by adding inert functional groups, such as methyl phosphonate, to the surface. To determine the effect of various surface-modification schemes on nanoparticle nonspecific binding, the interaction between functionalized silica nanoparticles and a DNA chip was also studied using confocal imaging/fluorescence microscopy. Dye-doped silica nanoparticles function...Continue Reading

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Citations

Nov 26, 2009·Archives of Toxicology·Guangping XieDawei Zhang
Feb 18, 2009·Analytical and Bioanalytical Chemistry·Wenwan Zhong
Aug 8, 2012·Analytical and Bioanalytical Chemistry·Robert I NooneyColette McDonagh
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Jun 5, 2007·Journal of the American Chemical Society·Massimo BottiniTomas Mustelin
Jul 7, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Bhuvnesh BhartiGerhard H Findenegg
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