Surface molecules involved in CD3-negative NK cell function. A novel molecule which regulates the activation of a subset of human NK cells.

International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement
A MorettaM C Mingari

Abstract

Natural killer cells are characterized by the lack of CD3/TCR molecules and by the expression of CD16 and CD56 (NKHI or Leu19) surface antigens. In addition to their ability to lyse certain tumor target cells, they release lymphokines including tumor necrosis factor and interferon gamma. Another unexpected functional capability of at least some NK cells is the ability to specifically recognize and lyse certain normal allogeneic cells (PHA-induced blasts). MAbs directed to CD2 or to CD16 surface molecules induced triggering of NK cells leading to target cell (p815) lysis in a redirected killing assay. Importantly, different from induction of T cell activation, single anti-CD2 MAbs were sufficient to trigger NK cell function. Another MAb (GL183) inducing NK cell triggering recognized a novel surface molecules expressed on 20-50% of resting or cultured NK cells. Cloned GL183+ cells displayed a variable degree of cytolytic activity against a number of human target cells of different histotype; moreover, this activity was strongly enhanced by the addition of GL183 MAb. On the other hand, GL183 MAb inhibited lysis of murine lines (including P815). Thus on P815 target cells GL183 MAb has an effect antithetical to that of other stimuli...Continue Reading

References

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Citations

Feb 28, 2009·The American Journal of Pathology·Stefan GattenlöhnerHans-Konrad Müller-Hermelink
Oct 1, 2013·Immunology Letters·Mariella Della ChiesaAlessandro Moretta
Nov 9, 2002·Immunology·Kei OhnumaChikao Morimoto
May 23, 2009·European Journal of Haematology·Stefano MolicaManlio Ferrarini
Jan 16, 2010·The FEBS Journal·Denise M T YuMark D Gorrell
Mar 30, 2013·The Journal of Clinical Endocrinology and Metabolism·Sang Ah LeeDae Ho Lee
May 23, 2013·British Journal of Haematology·Ryo HatanoChikao Morimoto
Mar 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kei OhnumaChikao Morimoto
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M NoriC Morimoto
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y MunakataC Morimoto

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