Surface morphology of rat peritoneal mast cells during in vitro regeneration after histamine secretion

Cell and Tissue Research
P BytzerJ Clausen

Abstract

Cell-surface morphology of regenerating mast cells was followed over a period of 48 h after histamine release. Control cells (not stimulated to secrete) were characterized by anastomosing folds of membrane of equal depth and width. During exocytosis these folds disappeared and were replaced by deep cup-shaped flaps of membrane evident in cells incubated for 10 min. During the first hours of regeneration these flaps fused mutually or with the plasma membrane. This activity suggests membrane retrieval, maybe specifically recycling the granule-type patches of membrane. Membrane-fusion activity was observed to some degree also after extended incubation. After 48 h of incubation the regeneration process was still not completed, as indicated by the fact that holes leading to intracellular cavities could still be found.

Citations

Apr 1, 1984·Agents and Actions·G Berlin, L Enerbäck
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L Thilo
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M DvorakD W Macglashan
Jan 1, 1991·Chemico-biological Interactions·G DecortiL Baldini

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