Surface pH buffering to promote degradation of mesoporous silica nanoparticles under a physiological condition

Journal of Colloid and Interface Science
Eunshil Choi, Sehoon Kim

Abstract

Despite significant advancement of mesoporous silica nanoparticle (MSN)-based biomedical research, studies have not been done enough to understand biodegradability of functional MSNs for better clinical efficacy. Polyethyleneimine (PEI) is one of the mostly used surface functionalities of MSNs, owing to the amine-rich chemical composition and the well-known proton sponge effect. In this paper, we study degradation behaviors of PEI-coated MSNs (PEI-MSNs) under a neutral or acidic physiological condition in comparison to those of surface-uncoated or nonionic F-127-encapsulated MSNs. The results showed that the surface coating by PEI could promote particle degradation in both neutral and acidic phosphate buffered saline (PBS) solution (i.e., pH 7.4 and 5.0). Importantly, we demonstrated that the local pH buffering by the surface PEI could lead to a greater total degradation quantity of particles even in the acidic PBS solution. The PEI-induced pH buffering phenomenon was confirmed by using a fluorescent pH indicator dye, fluorescein, which was attached to the surface of PEI-MSNs (F-PEI-MSNs). The observed pH-insensitive fluorescing behavior of fluorescein attained by surface coating with PEI corroborates the buffering effect that ...Continue Reading

Citations

Sep 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingshu CuiLu Xu
Oct 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sepanta HosseinpourChun Xu
Feb 5, 2021·International Journal of Nanomedicine·Xuan ShaJingjing Li
Aug 19, 2020·ACS Applied Materials & Interfaces·Seulbi Kim, Ji Hun Park

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