PMID: 6983239Jan 1, 1982Paper

Surface phenotype and migratory capability of Peyer's patch germinal center cells

Advances in Experimental Medicine and Biology
Eugene C ButcherI L Weissman

Abstract

Peanut agglutinin (PNA) binds selectively to germinal center cells in mouse peripheral lymphoid organs. Using PNA as a marker, we have determined that Peyer's patch germinal center cells are B cells with a unique phenotype---they express a low level of surface immunoglobulin (about 85% Ig+), predominantly of the IgA class (70% alpha+), with only 10% bearing surface IgM, and few if any expressing IgD. This phenotype identifies murine Peyer's patch germinal center cells as fairly late cells in B cell differentiation, and suggests that they may be precursors of IgA-secreting plasma cells in the gut wall. In addition, we have described a means of purifying PNA+ Peyer's patch lymphocytes, and have demonstrated that these cells lack functional receptors for high endothelial venules and fail to migrate to lymphoid organs in vivo. It is speculated that PNA may be a general marker for nonmigratory lymphocyte populations undergoing local differentiation.

Citations

Apr 1, 1992·Immunological Reviews·P NieuwenhuisH G Seijen
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A InlayYang Xu
Jul 1, 1984·The American Journal of Anatomy·P Nieuwenhuis, D Opstelten
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deepta BhattacharyaIrving L Weissman

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