PMID: 3756148Jul 29, 1986Paper

Surface properties of 1,2-dipalmitoyl-3-acyl-sn-glycerols

Biochemistry
D A Fahey, Donald M Small

Abstract

Stereospecific 1,2-dipalmitoyl-sn-glycerol and a series of 1,2-dipalmitoyl-3-acyl-sn-glycerols (TGs) with 3-acyl chains of two through six and eight carbons in length were synthesized. Pressure-area isotherms at 27 degrees C, surface melting temperatures (Ts), and equilibrium spreading pressures (esp) measured at the bulk melting temperature (Tf) were obtained for each TG and for dipalmitin. Whereas dipalmitin and the 3-acetyl-TG condense directly to an expanded mesomorphous state (30-33 A2/palmitoyl chain at the vapor pressure, pi v), the 3-propionyl- through 3-octanoyl-TGs show an area per molecule (in the liquid at pi v) that increases linearly from 105 to 130 A2/molecule (slope = 5 A2/CH2 group). This slope suggests that the 3-acyl chains are lying flat on the water at the end of the gas-liquid transition. Before solidification at 42-47 A2/molecule, the 3-propionyl- through 3-hexanoyl-TGs show a transition corresponding to the immersion of the 3-acyl chain. The pressure at this transition, pi tr, vs. 3-acyl carbon number is linear and indicates a chain immersion energy of 497 cal mol-1 per CH2. In contrast, the 3-octanoyl chain is not forced into the water but rather is pushed into the monolayer to lie parallel to the palmi...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.