Surface structures involved in target recognition by human cytotoxic T lymphocytes

Science
S C MeuerE L Reinherz

Abstract

Cloned human cytotoxic T lymphocytes and monoclonal antibodies inhibiting their function (anti-T3A, anti-T4A, and anti-T8A) were used to elucidate the role of T cell surface glycoproteins in cell-mediated lympholysis involving individual classes of gene products of the major histocompatibility complex on target cells. The results indicate that several surface molecules are required for specific target recognition: T3 and T4 on T4+ cytotoxic T lymphocytes and T3 and T8 on T8+ cytotoxic T lymphocytes.

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Citations

Mar 4, 1998·European Journal of Immunology·K A FortnerR C Budd
Jan 1, 1983·Immunogenetics·V H Engelhard, C Benjamin
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Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H D RoyerE L Reinherz
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A de la HeraC Martinez
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