Surface-tension measurements of pulmonary lavage from ozone-exposed rats

Journal of Toxicology and Environmental Health
J P NachtmanE S Wright

Abstract

Ozone, an important component of photochemical air pollution, has been shown to cause morphological and functional changes in the lung after acute, high-level exposure in controlled animal studies. Previous exposures of rats to 0.8 ppm ozone for 18 h showed trends toward decreased lung volumes, as well as modifications in phospholipid composition of lung lavage fluid. These results suggested that exposure to ozone may have diminished the ability of surfactant to reduce surface tension. The purpose of this pilot study was to determine if changes in the surface tension of lavaged pulmonary surfactant occur with ozone exposure. The lavage fluid from rats exposed to ozone at 0.8 ppm for 18 h had a 360% increase in protein and a 30% increase in lipid phosphorus content. Lung lavage samples from ozone-exposed rats were more potent in reducing surface tension as measured on a Wilhelmy plate balance. This difference was evident whether determined with half the total lavage or with equivalent microgram amounts of lipid phosphorus. It is concluded that at this dose and duration of ozone exposure, contrary to our hypothesis, surface-tension-lowering ability of surfactant increases and therefore does not appear to be a contributory factor ...Continue Reading

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Citations

Oct 1, 1988·Bulletin of Environmental Contamination and Toxicology·J P NachtmanR C Miles
Feb 16, 2006·Respiratory Physiology & Neurobiology·Natalie J MillerSandra Orgeig
Oct 10, 1998·European Journal of Clinical Investigation·B MüllerP J Barth
Aug 19, 2006·Journal of Applied Physiology·Richard A JohnstonStephanie A Shore
Feb 18, 2004·Journal of Applied Physiology·Y M Rivera-SanchezS A Shore

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