Surface thermodynamics of normal and pathological human granulocytes

Cell Biophysics
D R AbsolomA W Neumann

Abstract

Surface tensions of normal and pathological granulocytes were determined by (1) adhesion to solid substrates of different surface tensions while suspended in liquid media of different surface tensions, and by (2) measurement of cell-liquid-vapor contact angles obtained with sessile drops of saline water on cell monolayers. The results obtained by the two different methods were in close conformation with one another. With the cell adhesion method some residual leukocyte adhesion still persists even under conditions where there no longer is a van der Waals attraction between cells and solid substrate. At low ionic strength and by the abolishment of all multivalent cations through the admixture of EDTA, that residual cell adhesion virtually disappears (with normal as well as with pathological granulocytes), indicating that the earlier residual cell adhesion did indeed arise from electrostatic interactions mediated by multivalent cations (probably Ca2+). Comparison of the capacities for engulfment and the surface thermodynamics data of normal and pathological granulocytes obtained in this study leads to the novel observation that the phagocytic episode from half to complete engulfment of bacterial particles by granulocytes appears ...Continue Reading

References

Jan 1, 1978·Annual Review of Microbiology·C J van Oss
Feb 1, 1962·Biological Reviews of the Cambridge Philosophical Society·A S CURTIS

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Citations

Aug 1, 1988·Cell Biophysics·J M SchakenraadJ Arends
Dec 1, 1989·Experientia·C KrekelerJ Klein
Jan 1, 1984·Biomaterials, Medical Devices, and Artificial Organs·D R AbsolomA W Neumann
Feb 1, 1985·Journal of Oral Pathology·T E Van DykeR J Genco
Mar 1, 1983·Journal of Biomedical Materials Research·A W NeumannD R Absolom
Jan 1, 1983·Annals of the New York Academy of Sciences·A W NeumannC J van Oss
Jan 1, 1988·Journal of Biomedical Materials Research·G ChangW Zingg
Mar 1, 1988·Journal of Biomedical Materials Research·D R AbsolomA W Neumann
Apr 1, 1988·Journal of Biomedical Materials Research·D R AbsolomG Chang
Jul 1, 1983·Applied and Environmental Microbiology·D R AbsolomA W Neumann
Oct 1, 1985·Infection and Immunity·S A KlotzJ E Zajic

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