PMID: 15348619Sep 7, 2004Paper

Surface topography modulates the osteogenesis in human bone marrow cell cultures grown on titanium samples prepared by a combination of mechanical and acid treatments

Journal of Materials Science. Materials in Medicine
M G DinizM H Fernandes

Abstract

Titanium samples of different roughness R(a) and morphology were prepared using a combination of mechanical (grinding with a SiC paper or blasting with aluminum oxide particles with 65 or 250 microm) and chemical (attack with a sulphuric acid based solution or a hydrofluoric acid based solution) treatments. The biological performance of the prepared surfaces was evaluated using human bone marrow osteoblastic cell cultures. Mechanically treated samples presented different R(a) values and surface morphology. The hydrofluoric acid solution was more effective than the sulphuric acid solution in smoothing titanium surface and also in eliminating aluminum contamination resulting from the blasting process. Bone marrow cells seeded on the different titanium samples showed a similar pattern of behavior during cell attachment and spreading. Cells proliferated very well on all the titanium surfaces and cell growth was observed during approximately two to three weeks. The samples treated with the hydrofluoric acid solution presented higher alkaline phosphatase activity. Only the blasted samples treated with the acid solutions allowed seeded bone marrow cells to form a mineralized extracellular matrix. The best biological performance was fo...Continue Reading

Citations

Aug 12, 2009·Implant Dentistry·Guaracilei Maciel VidigalGlória de Almeida Soares
Nov 18, 2005·Brazilian Oral Research·Marilia Garcia DinizRicardo Guimarães Fischer
Jul 13, 2005·Journal of Biomedical Materials Research. Part a·Euler A dos SantosGloria A Soares
Oct 5, 2007·The Journal of Oral Implantology·Gintaras JuodzbalysTomas Baltrukonis
May 19, 2010·International Journal of Molecular Sciences·Yoshiki OshidaKoray Gençay
Nov 26, 2005·Brazilian Oral Research·Adriana Soares SantiagoGloria de Almeida Soares
Oct 27, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Hasret Tolga SirinErhan Piskin
Jan 11, 2008·Journal of Biomedical Materials Research. Part a·A CanabarroR G Fischer

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