Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone

International Journal of Oncology
Shohei YoshimotoMasato Hirata

Abstract

Ameloblastoma is the most common benign odontogenic tumor in Japan. It is believed that it expands in the jaw bone through peritumoral activation of osteoclasts by receptor activator of nuclear factor kappa-B ligand (RANKL) released from the ameloblastoma, as in bone metastases of cancer cells. However, the clinical features of ameloblastoma, including its growth rate and patterns of invasion, are quite different from those of bone metastasis of cancer cells, suggesting that different underlying mechanisms are involved. Therefore, in the present study, we examined the possible mechanisms underlying the invasive expansion of ameloblastoma in the jaw bone. Expression levels of RANKL assessed by western blotting were markedly lower in ameloblastoma (AM-1) cells than in highly metastatic oral squamous cell carcinoma (HSC-3) cells. Experiments coculturing mouse macrophages (RAW264.7) with AM-1 demonstrated low osteoclastogenic activity, as assessed by tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cell formation, probably because of low release of RANKL, whereas cocultures of RAW264.7 with HSC-3 cells exhibited very high osteoclastogenic activity. Thus, RANKL release from AM-1 appeared to be too low to generate ost...Continue Reading

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Citations

Nov 14, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shiying ShenYemei Qian
Apr 25, 2019·International Journal of Molecular Medicine·Xin LiuQian Tao
Mar 20, 2021·The Japanese Dental Science Review·Takao FuchigamiNorifumi Nakamura
Sep 12, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shohei YoshimotoShuichi Hashimoto

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