Surface vulnerability of cerebral cortex to major depressive disorder

PloS One
Daihui PengYiru Fang

Abstract

Major depressive disorder (MDD) is accompanied by atypical brain structure. This study first presents the alterations in the cortical surface of patients with MDD using multidimensional structural patterns that reflect different neurodevelopment. Sixteen first-episode, untreated patients with MDD and 16 matched healthy controls underwent a magnetic resonance imaging (MRI) scan. The cortical maps of thickness, surface area, and gyrification were examined using the surface-based morphometry (SBM) approach. Increase of cortical thickness was observed in the right posterior cingulate region and the parietal cortex involving the bilateral inferior, left superior parietal and right paracentral regions, while decreased thickness was noted in the parietal cortex including bilateral pars opercularis and left precentral region, as well as the left rostral-middle frontal regions in patients with MDD. Likewise, increased or decreased surface area was found in five sub-regions of the cingulate gyrus, parietal and frontal cortices (e.g., bilateral inferior parietal and superior frontal regions). In addition, MDD patients exhibited a significant hypergyrification in the right precentral and supramarginal region. This integrated structural ass...Continue Reading

References

Jun 14, 1975·Science·V S CavinessV S Caviness
Jan 1, 1988·Anatomy and Embryology·K ZillesH J Kretschmann
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Mar 15, 1994·The Journal of Comparative Neurology·M T LuP L Strick
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Apr 13, 2001·Current Opinion in Neurobiology·J C Culham, N G Kanwisher
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Oct 22, 2005·Behaviour Research and Therapy·Katharine A Rimes, Ed Watkins
May 9, 2007·Archives of General Psychiatry·Kathleen R MerikangasRonald C Kessler
Nov 1, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Manuel F Casanova, Christopher R Tillquist
Dec 14, 2007·Developmental Neuroscience·Adria PontiousRobert F Hevner
Mar 13, 2008·IEEE Transactions on Medical Imaging·Marie SchaerJean-Philippe Thiran
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Simone GrimmGeorg Northoff
Jul 22, 2008·Behavioural Neurology·Yasuhisa SakuraiToru Mannen
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yvette I ShelineMarcus E Raichle
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Feb 17, 2009·Neuroreport·Yuanchao ZhangTianzi Jiang
Apr 3, 2009·Annals of the New York Academy of Sciences·Tania Singer, Claus Lamm
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jason P Mitchell
Jun 26, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert HesterHugh Garavan
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Sep 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francine M Benes
Nov 17, 2009·Behavioural Brain Research·R Canbeyli
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angela R LairdPeter T Fox
Dec 5, 2009·Depression and Anxiety·Andrew W GoddardAnantha Shekhar
Mar 17, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P Cédric M P KoolschijnRené S Kahn
Apr 20, 2010·Behaviour Research and Therapy·Jennifer A SumnerSusan Mineka
Apr 22, 2010·CNS Neuroscience & Therapeutics·Mostafa El MansariPierre Blier
Oct 19, 2010·Biological Psychiatry·Petra HabetsUNKNOWN Genetic Risk and Outcome of Psychosis (G.R.O.U.P)
Oct 29, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nikhil M UrsMarc G Caron
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonas A HospAndreas R Luft

❮ Previous
Next ❯

Citations

Apr 20, 2016·Translational Psychiatry·M E McLarenV M Dotson
Aug 10, 2016·Scientific Reports·Chen ZhangYiru Fang
Oct 16, 2016·Brain Imaging and Behavior·Yuli FradkinMichael C Stevens
Nov 7, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Qian LiQiyong Gong
Jun 4, 2020·CNS Neuroscience & Therapeutics·Jin-Lei ZhaoGuo-Rong Liu
Aug 19, 2018·Molecular Psychiatry·Aleksandra TomicMassimo Filippi
Jun 7, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Kathrin NickelSimon Maier
May 10, 2020·European Archives of Psychiatry and Clinical Neuroscience·Iris DalhuisenIndira Tendolkar
Feb 6, 2020·Frontiers in Neurology·Mateus Henrique NogueiraFernando Cendes
May 28, 2017·Journal of Alzheimer's Disease : JAD·Anna PinkYonas E Geda
Apr 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Daisuke SawamuraKhin K Tha
Nov 17, 2020·Psychological Medicine·Kwan Woo ChoiByung-Joo Ham
Dec 15, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fabio SambataroSimona Spinelli
Apr 28, 2021·Biological Trace Element Research·Mehran Shayganfard
Aug 18, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jee Su SuhBenicio N Frey

❮ Previous
Next ❯

Software Mentioned

FreeSurfer

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.